Melia Azedarach L. Fruit Extract Effect on Plasma Lipid Profile and Cardiac and Hepatic Functions of Diabetic Rats
Journal Title: Iranian Journal of Diabetes and Obesity - Year 2017, Vol 9, Issue 4
Abstract
Objective: There are controversial reports about biological effects of the Melia Azedarach Linn. (MA). In the present study, the effect of MA fruit extract on lipid profile, cardiac and hepatic functions of diabetic rats was investigated. Materials and Methods: Thirty male Wistar rats were divided into five groups. Group 1 as the control group, Group 2 as the diabetic group, Group 3 and 4 as the diabetic rats treated with MA fruit extract (100 and 200 mg/kg for 30 days, orally) and Group 5 as the positive control group treated by Glibenclamide (0.5 mg/kg for 30 days). Diabetes was induced by nicotine amide and streptozotocin. After 30 days, the plasma concentration of glucose, hemoglobin A1C (HbA1c), lipid profile, hepatic enzymes were measured. Also, electrocardiogram and interventricular pressures were recoded. Results: The data showed that the plasma levels of glucose, HbA1c, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase were significantly increased in the diabetic group. These parameters were higher in groups treated with MA extract, without significant difference. The plasma lipid profile significantly changed in diabetic rats and did not come back to normal level in groups treated with MA extract. Compared to the control group, corrected QT interval was increased and the rate of interventricular pressure changes decreased in all groups. MA extract was as an antioxidant compound against diphenylpicrylhydrazyl (DPPH) free radicals. Conclusion: These results demonstrated that although MA extract had an antioxidant effect, it did not improve the signs of diabetes in diabetic rats.
Authors and Affiliations
Omid Afkhami-Ardekani, Mansour Esmailidehaj, Mohammad Afkhami Ardekani, Hassan Esmaeili, Arezoo Afkhami-Ardekani
Keywords
Related Articles
- EP ID EP636079
- DOI -
- Views 57
- Downloads 0
The Assosiation of Carotid Intima-Media Thickness and Ankle Brachial Index with SPECT Myocardial Perfusion Imaging in Asymptomatic Diabetic Patients
Objective: The risk of cardiac death in diabetic patients is 3 times more than non-diabetics. But it is not determined who need cardiac screening. About 41% of diabetic patients with silent ischemia are missed. the carot...
Atherosclerosis Surrogate Marker in Diabetic Patients
Objective: Duplex ultrasonography is a non-invasive, non-expensive screening test for carotid disease. Intima media thickness (IMT) is appropriate for atherosclerosis process diagnosis. Leukoaraisis (LA) increase the ris...
Bulimia in Diabetic Patients: A Review on Diabulimia
Objective: Eating disorder (bulimia) is common in young diabetic patients which may influence insulin levels. To reduce calories by manipulating insulin is known as Diabulimia. The purpose of this paper is to define Diab...
Impact of Magnesium Deficiency on Pancreatic β-Cell Function in Type 2 Diabetic Nigerians
Objective: Pancreatic -cell dysfunction is described to be present at the diagnosis of type 2 diabetes mellitus (T2DM) and progressively deteriorated with disease duration. However, its progression is variable and poten...
Diabetes Mellitus and Impairment of Male Reproductive Function: Role of Hypothalamus Pituitary Testicular Axis and Reactive Oxygen Species
Diabetes mellitus (DM) is one of the greatest public health threats in modern societies. Although during a few years it was suggested that DM had no significant effect in male reproductive function, this view has been ch...