Memory enhancing activity of Momordica charantia by scopolamine induced amnesia in rats
Journal Title: IP International Journal of Comprehensive and Advanced Pharmacology - Year 2017, Vol 2, Issue 1
Abstract
The present study was undertaken to investigate the effect of Momordica charantia on cognitive functions, total cholesterol levels and cholinesterase (ChE) activity in scopolamine-induced amnesia in rats. The paste of Momordica charantia was administered orally at three doses (150, 300 and 600 mg/kg) for 7 and 14 consecutive days to the respective groups of rats. Piracetam (200 mg/kg) was used as a standard nootropic agent. Learning and memory parameters were evaluated using elevated plus maze (EPM), passive avoidance and motor activity paradigms. Brain ChE activity and serum biochemical parameters like total cholesterol, total triglycerides and glucose were evaluated. It was observed that Momordica charantia at the above-mentioned doses after 7 and 14 days of administration in the respective groups significantly reversed scopolamine (1 mg/kg i.p.)-induced amnesia, as evidenced by a decrease in the transfer latency in the EPM task and step-down latency in the passive avoidance task. Momordica charantia reduced the brain ChE activity in rats. Momordica charantia also exhibited a remarkable cholesterol and triglyceride lowering property and slight increase in glucose levels in the present study.
Authors and Affiliations
Ankur Joshi, Priyanka Soni, Sapna Malviya, Anil Kharia
Keywords
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