META ANALYSIS OF ANTIEPILEPTIC DRUGS INDUCED CHOREOATHETOSIS IN PAEDIATRIC PATIENTS
Journal Title: International Journal of Medical Reviews and Case Reports - Year 2017, Vol 1, Issue 3
Abstract
BACKGROUND: The safety profile of anti-epileptic drugs (AEDs) is an important consideration for the regulatory bodies, owners and prescribing clinicians. Meta-analysis has increasingly been used to identify adverse effects of drugs. Efficacy studies are often too small to reliably assess risks that become important when a medication is in widespread use, so meta-analysis, which is a statistically efficient way to pool evidence from similar studies, seems like a natural approach. The safety profile of drugs is an important consideration and it affects clinicians’ decisions to prescribe specific AED(s), as serious adverse effects can lead to chronic complications or even death. Less serious, but nonetheless important, adverse effects can significantly impact quality of life, leading to systematic illness which may increase the overall cost of treatment METHODS: An electronic search was performed in using Pubmed,Paediatric journals of Neurology, MEDLINE etc. RESULTS: The literature search identified 30 unduplicated papers. Of these 11 papers were excluded by reading the abstracts and titles. Another 10 papers were excluded after reading their complete text. We selected 9 papers which comprised of case studies and observational studies. CONCLUSION: The combination of different antiepileptic drugs has resulted in drug induced choreoathetosis. A particular increased risk was seen with combinations that have phenytoin and lamotrigine. This could be due to an additive or a synergistic effect on central dopaminergic pathways.
Authors and Affiliations
Sriram Shanmugam, Lidhu Daniel, Dr. Jaleel Ahamed
Keywords
Related Articles
- EP ID EP428038
- DOI 10.5455/IJMRCR.ANTIEPILEPTIC-DRUGS-INDUCED-CHOREOATHETOSIS
- Views 161
- Downloads 0
A case report of a high voltage electrical injury: Lower limb Salvage with age-old technique of bone trephination and Split-thickness skin grafting
Introduction: Electrical injuries make up a relatively small portion of burn injuries. In electrical burns limb damage is severe. Open wounds with bone exposed should be debrided properly and attempt of drilling can be g...
Asymptomatic vesical stone randomly discovered in a 78 years old woman admitted for femoral neck fracture. A case report
Urinary tract stones originate from a variety of conditions, including metabolic and inherited disorders, medical devices, anatomical defects with or without chronic urinary infection. Most cases are idiopathic, in which...
Los hombres y los accidentes de tránsito: un vistazo al riesgo, conducta de riesgo, notificación de accidentes, educación y formación profesional
Los accidentes de tránsito son un grave y complejo problema de salud pública. La literatura señala que los accidentes de tránsito están asociados confactores de comportamiento, seguridad de los vehículos y la precariedad...
Cost economics of endovascular coiling versus surgical clipping of intracranial aneurysm: Literature review and critical analysis
Background Cost-effectiveness of medical intervention is becoming increasingly important in healthcare delivery, treatment in Neurosurgery is very expensive and there have been very few publications on neurosurgical heal...
SURGICAL MANAGEMENT OF TRAUMATIC MANUBRIO-STERNAL DISLOCATION WITH LOCKING COMPRESSION PLATE: A CASE REPORT AND REVIEW OF LITERATURE
Background: Manubriosternal joint dislocation as a result of trauma is rare with only few case reports published in literature. Materials that have been used for fixation of displaced manubriosternal joint are steel wire...