Metastatic apocrine sweat gland adenocarcinoma in a terrier dog
Journal Title: Asian Pacific Journal of Tropical Biomedicine - Year 2012, Vol 2, Issue 8
Abstract
This report describes the clinical and pathological aspects of an apocrine sweat gland carcinoma with distant metastasis in an aged dog. A 7-year-old male terrier dog was referred to small animal hospital of Shahid Bahonar University of Kerman with a 5.5×3.5 centimeter pedunculated mass on its head near left auricular region which had been progressively growing since three months ago. The radiography showed no local and distant metastasis. Surgical excision and histological evaluation was done. Histologically, the mass was composed of epithelial cells arranged in glandular and solid patterns. The morphologic findings suggested either a primary or metastatic apocrine-gland carcinoma. Immunohistochemically, the tumor cells were intensely positive for cytokeratin 7 and 20 and negative for S100 protein. On the basis of histopathological and clinical findings, the tumor was diagnosed as a malignant apocrine gland tumor, arising from apocrine sweat glands of the skin. Local tumor recurrence with anorexia and weight loss was reported by the owner nine month later. Severe submandibular and prescapular lymphadenomegaly was noted in clinical examination. Several large pulmonary nodules were noted in chest radiographs resembling mediastinal lymph node metastasis. Second surgery and chemotherapy was rejected by the owner due to grave prognosis of the patient. The animal was died 45 days later due to respiratory complications. Tumors of apocrine sweat glands are relatively uncommon in dogs whereas apocrine gland adenocarcinoma with distant metastasis is extremely rare.
Authors and Affiliations
Akhtardanesh Baharak, Kheirandish Reza, Dabiri Shahriar, Azari Omid, Vosoogh Daruoosh, Askari Nasrin
Keywords
Related Articles
- EP ID EP257145
- DOI 10.1016/S2221-1691(12)60118-X
- Views 66
- Downloads 0
Emergence of staphylococcal cassette chromosome mec type I with high-level mupirocin resistance among methicillin-resistant Staphylococcus aureus
Objective: To investigate the molecular epidemiology and antimicrobial resistance patterns of methicillin-resistant Staphylococcus aureus (MRSA) among healthcare workers and patients. Methods: MRSA isolates were recovere...
Analysis of chemical composition and bioactive property evaluation of Indian propolis
Objective To analyze the chemical composition and to evaluate the bioactive potential of hydroalocoholic extract of propolis. Methods Ethanol extract of propolis was analyzed by GC-MS, HPTLC and HPLC methods and in vi...
Cladogynos orientalis Zipp. extracts inhibit cell culture-derived hepatitis C virus genotype 2a replication in Huh-7 cells through NS5B inhibition
Objective: To evaluate the potential anti-hepatitis C virus (HCV) activities of Cladogynos orientalis Zipp. ex Span and to investigate the molecular mode of action. Methods: Ethanolic and water extracts from various par...
Antifungal activity of four honeys of different types from Algeria against pathogenic yeast: Candida albicans and Rhodotorula sp.
Objective To evaluate the antifungal activity of four honeys of different types from Algeria against pathogenic yeast i.e. Candida albicans (C. albicans) and Rhodotorula sp. Methods Four Algeria honeys of different bo...
Comparison of antioxidant capacity and 毩-glucosidase inhibitory activity between bitter melon (Momordica charanti) fruit and leaf extract
Objective: To compare the physiologically active substances, antioxidant and antidiabetic activities in vitro of bitter melon fruit and leaf extract. Methods: Total polyphenol and flavonoid contents were measured using s...