METASTATIC NEUROENDOCRINE CARCINOMA OF THE PROSTATE PRESENTING WITH DISSEMINATED INTRAVASCULAR COAGULATION: IMPORTANT CLUES FROM A PERIPHERAL BLOOD SMEAR EXAMINATION
Journal Title: International Journal of Medical Laboratory Research - Year 2017, Vol 2, Issue 1
Abstract
Prostate cancer commonly metastasizes to bone, liver and lung but bone marrow (BM) involvement is rare. Most common coagulopathy in prostate cancer is Disseminated Intravascular Coagulation (DIC) with 0.4% to 1.65% of patients presenting with subclinical DIC.The Leucoerythroblastic reaction on the peripheral blood smear in this case prompted for a Bone Marrow(BM) examination leading us to the diagnosis in conjunction with the clinical and radiological findings. We report a case of Large Cell Neuroendocrine Carcinoma (LCNEC) of prostate with first presentation as bone with bone marrow metastasis and chronic DIC. Our case confirms the fact that such presentation is rare with an aggressive clinical course and poor prognosis. It also highlights the possibility of coagulopathy in such cases. The fact that DIC in LCNEC of prostate has not yet been reported in the literature makes our case report unique.
Authors and Affiliations
Monali Gupta, Deepak Dabkara, Indranil Mallick, Saugata Sen, Soumendranath Ray, Michael A. Linden, Mammen Chandy, Deepak Kumar Mishra
Keywords
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- EP ID EP278603
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