METHANOL AND WATER EXTRACTS OF COSTUS SPECIOSUS (J.KÖNIG) SM. LEAVES REVERSE THE HIGH-FAT-DIET INDUCED PERIPHERAL INSULIN RESISTANCE IN EXPERIMENTAL WISTAR RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 2
Abstract
Worldwide prevalence of insulin resistance is growing rapidly and there is no specific treatment for this condition. Medicinal plants are being used as sources of novel drug discovery. The objective of this study was to investigate the effect of methanol and water extracts of Costus speciosus leaf on insulin resistant experimental Wistar rats. Male Wistar rats were divided into five groups (n = 6) and IR was induced by a high fat diet (19.13 % fats). CS leaf methanol extract and water extract were prepared. Rats were treated daily for four weeks with the extracts. Group 1: 0.5 % CMC 1 ml, Group 2: 500 mg/kg/day methanol extract in CMC, Group 3: 500 mg/kg/day water extract in CMC, Group 4: 1500 mg/kg/day water extract in CMC, Group 5: Pioglitazone 10 mg/kg/day. Serum was analysed for glucose, triglycerides and insulin at baseline and after the therapy. Insulin resistance was calculated using indirect indices; HOMA, QUICKI and McAuley. Data were analysed by one- way ANOVA followed by Bonferroni post-hoc test and student’s t-test. Test values of p < 0.05 were considered statistically significant. Both CSlwex (at doses 500 and 1500 mg/kg) and CSlmex (500 mg/kg) significantly reduced (p < 0.05) insulin resistance and serum insulin level within four weeks therapy. Further, 500 mg/kg CSlmex reduced serum triglyceride level by 8.98 % in IR rats. Both Costus speciosus leaf water and methanol extracts have potent effect on reducing IR in experimental rats. Therefore, Costus speciosus leaf might be useful as a good source of insulin sensitizing chemical compounds.
Authors and Affiliations
Subasinghe Hewa Sewwandi, Hettihewa Menik, Gunawardena Sampath, Liyanage Thusharie
Keywords
Related Articles
- EP ID EP99299
- DOI 10.7897/2230-8407.050209
- Views 124
- Downloads 0
STUDY OF SERUM URIC ACID IN CHRONIC LIVER DISEASE AND ITS RELATION WITH OTHER PARAMETERS
In chronic liver disease, high uric acid levels are independently associated with severe disease and poor prognosis. However, studies regarding the relation of uric acid levels with different parameters of liver dysfunct...
STUDY OF THE ANTIHYPERLIPIDEMIC, ANTIOXIDATIVE AND ANTIATHEROGENIC ACTIVITY OF TRITICUM AESTIVUM LINN. IN RABBIT RECEIVING HIGH FAT DIET
The aim was to study of the antihyperlipidemic, antioxidative and antiatherogenic activity of Triticum aestivum Linn. in rabbit receiving high fat diet. Twenty rabbits of either sex were taken and divided into four group...
A PROSPECTIVE STUDY OF ANTITUBERCULOSIS DRUG-INDUCEDHEPATOTOXICITY AND ITS MANAGEMENT IN A TERTIARY CARE HOSPITAL
Tuberculosis (TB) is a very common form of droplet infection. If untreated, the disease may be fatal within 5 years in more than half of cases. To study the frequency of anti-tuberculosis therapy (ATT) induced hepatotoxi...
REVIEW / PHARMACOLOGICAL ACTIVITY OF PLATYCLADUS ORIEANTALIS
Platycladus orientalis, also known as Chinese Arborvitae or Biota. It is native to northwestern China and widely naturalized elsewhere in Asia east to Korea and Japan, south to northern India, and west to northern Iran....
A NOVEL VALIDATED RP-HPLC METHOD FOR THE DETERMINATION OF QUETIAPINE FUMARATE IN BULK AND PHARMACEUTICAL TABLET DOSAGE FORMS: APPLICATION TO DISSOLUTION STUDY
A simple, specific, accurate, rapid, inexpensive isocratic Reversed Phase-High Performance Liquid Chromatography (RP-HPLC) method was developed and validated for the quantitative determination of Quetiapine Fumarate in p...