Method development and validation for simultaneous determination of Telmisartan and Ramipril by UV Spectrophotometry
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2016, Vol 3, Issue 4
Abstract
A simple, validated, accurate and precise simultaneous UV Spectrophotometric method has been developed for the simultaneous estimation of Telmisartan (TEM) and Ramipril (RAM) in pharmaceutical dosage form. Telmisartan exhibits absorption maximum at 254.4nm and Ramipril shows absorption maximum at 209nm in methanol. The Beer’s law obeyed the concentration range of 2-12µg/ml for both TEM and RAM. Mean recovery of 99.14% for TEM and 99.05% for RAM respectively signifies the accuracy of the method. The method was validated as per ICH guidelines. The method shows good linearity, accuracy, precision, limit of detection and limit of quantification. This method can be successfully employed for the routine simultaneous estimation of TEM and RAM in pharmaceutical dosage forms.
Authors and Affiliations
Lakshmana Rao A, Prasanthi T, Anusha J, Prasanna MR, Jyothi P
Keywords
Related Articles
- EP ID EP240777
- DOI -
- Views 99
- Downloads 0
Hepatoprotective activity of ethanol extract of PAVETTA INDICA LINN leaves
Objective To investigate the hepatoprotective activity of ethanol extract of Pavetta Indica Linn leavesTraditionally the bark of Pavetta Indica Linn in decoction or pulverized is administered especially to children to co...
Attenuation of Sub Acute Inflammation by Ethanol Extract of Clerodendrum viscosum Linn. Leaves in Wistar Albino Rats
Inflammation is a pathological response of vascular tissue for harmful stimuli caused by injury, infection, environmental agents, malignancy and cellular changes. In our study we have tried to evaluate attenuation effect...
Cardioprotective and antihyperglycemic activity of vildagliptin in presence of nifedipine on adrenaline induced hyperglycemic rat
Generally there is higher prevalence of co-morbidity of diabetes and hypertension. Mortality increases more than 7 times when patient is having diabetes along with hypertension. In India 6.4% to 55% prevalence of hyperte...
Anaphylaxis to parenteral ciprofloxacin in mother leading to foetal death
Anaphylaxis is a rare condition during ante natal care since most of the drugs except nutraceuticals are avoided in pregnancy unless essentially required to prevent developing foetus from any teratogenic effects. An anap...
Prescribing pattern of antibiotics in lower respiratory tract infection among children aged less than 5 years
Introduction: Acute respiratory infection (ARI) is the largest cause of morbidity across the world in children under five years of age. Antibiotics are the most commonly prescribed medications for Lower respiratory tract...