METHOD DEVELOPMENT AND VALIDATION OF LEVOCETRIZINE BULK POWDER AND PHARMACEUTICAL FORMULATION WITH UV SPECTROPHOTOMETRIC ANALYSIS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 5
Abstract
The aim of this work was to develop and validate a simple estimation method of Levocetrizine in bulk powder and tablet using spectrophotometric method. The method was developed using methanol as a solvent & absorbance was measured at 230nm. Beers law was obeyed in the concentration range of 5-30 μg/ml. Calibration curves shows a linear relationship between the absorbance and concentration. The line equation y=0.0296x+0.0562 with r2 of 0.996 was obtained. Simple, accurate and cost efficient spectrophotometric method has been developed for the estimation of Levocetrizine in bulk powder and Tablet dosage form.
Authors and Affiliations
Swati Chauhan , Dharti Dasadiya , Shilpa Patel , Digbijay Kumar , Nurudin Jivani
Keywords
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