Microalbuminuria and Serum Creatinine Levels in Diabetic and Non-Diabetic Group - A Comparative Study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 3
Abstract
To compare the concentrations of Serum creatinine and urine albumin creatinine ratio (UACR) and to detect early decline in GFR in type 2 Diabetic patients and controls .80 proven cases of type 2 Diabetic patients &50 age and sex matched healthy controls.Fasting plasma glucose byTrinder's method, Serum& urine creatinine byJaffe’ s Method, urine dipstick analysis for protein, urine albumin byImmunoturbidimetry method , & calculated Urinary albumin creatinine ratio(UACR ) were estimated. Glomerular filtration rate was estimated based on the Serum Creatinine concentrations according to Modification of Diet in Renal Disease (MDRD).In 80 cases, 48 comes under Normoalbuminuria & 32 under microalbuminuria.There was increase in the levels of FPG,Sr Creatinine & urine albumin significantly (p<0.01) with increasing urinary albumin creatinine ratio. In this study, the estimated GFR tend to decrease with increasing degrees of albuminuria (P = <0.01) but in controls it was more. Pearson’s correlation coefficient (r) shows significant positive correlation between Serum creatinine and DM duration, FPG, UACR and there was a negative correlation between eGFR( r = -0.96 , p = < 0.001) .We concluded that type 2 DM patients who are at risk of developing renal impairment must be regularly monitored for microalbuminuria, Serum Creatinine, UACR, & eGFR irrespective of urine microalbumin levels.
Authors and Affiliations
Dr. P. Sudha Rani, Dr. Y. B. D. Suchetha, Dr. P. Srinivasa Rao, Dr. M. Sarala
Keywords
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