Microbiota Evaluation and Extracellular Cytokine Profile in Patients Affected with Intraabdominal Infection
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 15, Issue 4
Abstract
Failures in the control of infectious focus may be associated with Intra-abdominal infections (IAI)-driven sepsis. We evaluated the bacterial antimicrobial profile and the cytokine production in patients with IAI in Belo Horizonte, Brazil. To the analyses, Vitek 2 bioMérieux and BD-CBA Human Inflammatory Cytokines were used. Escherichia coli, Enterococcus faecalis and Bacteroides fragilis were predominant in this cohort. Enterobacteriaceae was resistant to at least 4 different antimicrobial classes and 80.0% of Acintobacter baumannii strains to imipenem. 81.8% of Staphylococcus spp. were methicillin-resistant. Penicillin and clindamycin resistance were found in 80.0% and 26.7% of anaerobes, respectively. IL-8 was found in all IAI secretions and in 93.5% of analyzed sera; while IL-6 was identified in 93.5% of patient’s serum and in 51.6% analyzed secretions. IL-10 was detected in 53.3% of patient’s serum. Our data indicates the relevance of further cytokine profile studies to better understanding the evolution of these processes.
Authors and Affiliations
João Fernando Gonçalves Ferreira, João Baptista Rezende-Neto, Rogério Augusto Pinto-Silva, Jaqueline Gontijo de Souza, Luiz de Macêdo Farias, Maria Auxiliadora Roque de Carvalho, Helton Santiago, José Carlos Serufo, Simone Gonçalves dos Santos
Keywords
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- EP ID EP341183
- DOI 10.9734/BJMMR/2016/25281
- Views 109
- Downloads 0
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