Micronuclei and its application in grading of oral squamous cell carcinoma
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2019, Vol 5, Issue 4
Abstract
Introduction: Presence of micronuclei has been seen in exfoliated oral epithelial cells. This has been correlated with severe genotoxic damage measured in terms of grading of the lesions. Aim: To correlate frequency of micronuclei (MN) in oral exfoliated cells in cases of oral squamous cell carcinoma (OSCC). Methods: The study subjects consisted of 20 clinically diagnosed cases of OSCC. 10 healthy subjects without any tobacco consumption habits formed the control group. After informed consent, exfoliated cells were collected from both groups using a wooden spatula and spread on slides, fixed, stained using Papanicolaou stain and subjected to microscopic examination. MN were counted in all cases and calculated. Results: The frequency of MN was three to four times higher in patients with OSCC as compared to patients in the control group and the difference was found to be highly significant. MN frequencies were also found to be raised with increasing histological grades of squamous cell carcinoma. Conclusions: Micronuclei serve as a biomarker for prediction of the grade of OSCC
Authors and Affiliations
Dr. Nawal Khan, Dr. Munaza Shafi
Keywords
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- EP ID EP575339
- DOI 10.22192/ijcrms.2019.05.04.008
- Views 146
- Downloads 0
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