MicroRNAs as Potential Therapeutic Targets in Peripheral Arterial Disease
Journal Title: International Journal of Diabetology & Vascular Disease Research (IJDVR) - Year 2014, Vol 2, Issue 7
Abstract
Micro RNAs (miRNAs)are small non-coding RNAs that play a role in many biological processes. Many studies have shown that miRNAs are involved in ischemic conditions and emphasized their role as negative or positive modulators in angiogenesis. In vivo studies using various models bring light to the potential benefits of these miRNAs in perfusion recovery following surgically induced hind limb ischemia (HLI), a model of Peripheral arterial disease (PAD). PAD remains a major healthcare burden, affecting millions of Americans.With little advancement in effective therapy the morbidity and mortality of this disease continues to rise. A better understanding of how miRNAs modulate perfusion recovery may provide a potential effective therapy for PAD.
Authors and Affiliations
Ayotunde Dokun
Keywords
Related Articles
- EP ID EP198727
- DOI 10.19070/2328- 353X-140001
- Views 108
- Downloads 0
Epigenetics and Diabetes: Current and Perspective.
Diabetes has reached epidemic proportions throughout the world. Increasing evidence suggests that complex interactions between genes and the environment might play a major role in the pathogenesis of this mutlifactoriel...
Walking Economy is Impaired in Older Men and Women with Type 2 Diabetes
Objective: We compared the walking economy in older participants with and without type 2 diabetes. Methods: Walking economy was determined in 115 older participants with type 2 diabetes and 130 older control participants...
Diabetes Mellitus And The Brain: Special Emphasis To Cognitive Function
Diabetes mellitus (DM) is a major public health problem. Cognitive deficits are common with DM which range from subclinical or subtle to severe deficits as dementia. Both hypoglycemia and hyperglycemia are causes of cogn...
Harmonizing Eating and Exercise Circadian Rhythms for Optimal Glucose-Insulin and Vascular Physiology.
This article establishes a global but individual public program based on rhythmic circadian eating and exercise extent and rate to harmonize intermediary metabolism. This will help optimize glucose assimilation and insul...
Diabetic Foot Lesions on Rise, Investigating Predicting Factors in a Developing Country
Background: Diabetic foot lesions (DFL) are one of the devastating complications of diabetes mellitus (DM). Numerous factors interlinked to cause DFL which starts as ulcer & end up as amputation. Apart from the direct ef...