Microstructural Analysis of Porous Composite Materials: Dynamic Imaging of Drug Dissolution and Diffusion Through Porous Matrices

Journal Title: The AAPS Journal - Year 2008, Vol 10, Issue 4

Abstract

Inert matrix tablets (ferrous sulphate-Ferrogradumet®, Abbott Laboratories, Australia) were used as supplied. Each tablet contained 375 mg ± 5% of ferrous sulphate, which is approximately 105 mg of elemental iron. The matrix consisted of lactose and Eudragit®. Water was purified by reverse osmosis (MilliQ, Millipore, France).

Authors and Affiliations

Paul M. Young, Kathy Nguyen, Allan S. Jones, Daniela Traini

Keywords

Related Articles

Evaluation of the antioxidant activity of different flavonoids by the chemiluminescence method

The objective of the present investigation was to study the antioxidant action of different flavonoids (quercetin, glabridin, red clover, and Isoflavin Beta, an isoflavones mixture) in order to determine if they could be...

Rheology and stability of water-in-oil-in-water multiple emulsions containing Span 83 and Tween 80

Multiple emulsions are often stabilized using a combination of hydrophilic and hydrophobic surfactants. The ratio of these surfactants is important in achieving stable multiple emulsions. The objective of this study was...

Monitoring intracellular pH changes in response to osmotic stress and membrane transport activity using 5-chloromethylfluorescein

Intracellular free H+ concentration (pHi) responds to numerous extracellular stimuli. The use of fluorescent indicator dyes to measure pHi is strongly influenced by the ability of target cells to retain activated dye wit...

Evidence of effectiveness: How much can we extrapolate from existing studies?

Drug development can be a science of extrapolation if the use of a drug exposure-response relationship is embraced and implemented through mechanistically oriented pharmacokinetic (PK)-pharmacodynamic (PD) modeling analy...

Pharmacokinetic and Pharmacodynamic Modeling of a Monoclonal Antibody Antagonist of Glucagon Receptor in Male ob/ob Mice

Elevated basal concentrations of glucagon and reduced postprandial glucagon suppression are partly responsible for the increased hepatic glucose production seen in type 2 diabetic patients. Recently, it was demonstrated...

Download PDF file
  • EP ID EP681622
  • DOI  10.1208/s12248-008-9063-2
  • Views 73
  • Downloads 0

How To Cite

Paul M. Young, Kathy Nguyen, Allan S. Jones, Daniela Traini (2008). Microstructural Analysis of Porous Composite Materials: Dynamic Imaging of Drug Dissolution and Diffusion Through Porous Matrices. The AAPS Journal, 10(4), -. https://www.europub.co.uk/articles/-A-681622