Microwave Synthesis and Antimicrobial Activity of Novel Metal-Complexes with Schiff Base 2, 5-Thiophene Dicarboxaldehyde-Thiosemicarbazone
Journal Title: Scholars Academic Journal of Pharmacy - Year 2014, Vol 3, Issue 5
Abstract
Some novel Schiff base metal complexes of Cr(III), Co(II), Ni(II) and Cu(II) derived from 2,5- Thiophene dicarboxaldehyde-Thiosemicarbazone (TDATC) was synthesized by conventional as well as microwave methods. This compound was characterized by elemental analysis, FT-IR, Mass, molar conductance and magnetic susceptibility measurements analysis. Analytical data revealed that all the complexes habited 1:1 (metal: ligand) ratio with a coordination number of six. The IR data showed that the ligand coordinates with the metal ions in a hexa-dentate manner. The solid state electrical conductivity of the metal complexes was also measured. Solid state electrical conductivity studies reflected a semi-conducting nature of the complexes. The Schiff base and metal complexes displayed good activity against the Gram-positive bacteria Staphylococcus aureus, the Gram-negative bacteria Escherichia coli and the fungi Aspergillus niger and Candida albicans. The antimicrobial results also indicated that the metal complexes displayed better antimicrobial activity as compared to the Schiff bases. Keywords: Microwave method, Hexa-dentate ligands, Biological activities
Authors and Affiliations
Mohammed Fakruddin Ali Ahamed, Venkatesan Jayakumar
Keywords
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