Modern view on the etiology, pathogenesis and possibilities of diagnostics of external genital endometriosis
Journal Title: Медичні перспективи - Year 2019, Vol 24, Issue 1
Abstract
Endometriosis is a condition that determines the presence of functionally active glands and endometrial stroma outside the uterus, causing a chronic inflammation in these tissues. The prevalence of endometriosis varies between 5-10% for all women, 20-25% for gynecological patients and reaches 45-50% for women with infertility. The true frequency of endometriosis is not definitely known, and its growth over the past decades is associated with both the increasing frequency of the disease and the improvement of its diagnosis. Endometriosis occurs irrespective of ethnicity and race, socioeconomic conditions, at any age. Diagnosis of external genital endometriosis includes patients’ complaints, clinical examination, ultrasound examination, sometimes magnetic resonance imaging. Much has been done to understand the mechanisms of endometriosis, but still the "gold standard" of diagnosis is invasive methods, especially laparoscopy. An early diagnosis will allow to timely develop treatment tactic aimed at treating endometriosis and preventing its further spread and recurrence. The search for possible biomarkers for the diagnosis of endometriosis continues. Among non-invasive methods, the most promising for future study and research is the microRNA and long non-coding RNA. Molecular genetic methods in achieving good sensitivity and specificity results will be able to improve the results of infertility treatment associated with endometriosis through earlier treatment including surgery. In addition, various research groups have high expectations regarding the role of microRNA and long non-coding RNA chains in evaluating the effectiveness of drug therapy. The purpose of this review was to collect and analyze data from the world’s literature, search for new non-invasive markers for diagnosing this disease at the preclinical stages, as well as predicting the response to hormone therapy.
Authors and Affiliations
M. V. Medvedev, D. A. Pokrovenko
Keywords
Related Articles
- EP ID EP594895
- DOI 10.26641/2307-0404.2019.1.162173
- Views 112
- Downloads 0
Профілактика порушень поведінкових реакцій щурів при застосуванні ноотропів з вальпроатом натрію
Применение противосудорожных средств может провоцировать ряд побочных эффектов, в том числе возможны изменения поведения и психоэмоционального состояния людей, больных эпилепсией, вероятно появление немотивированной агре...
Long-term results of organ-preserving treatment of uterine leiomyoma combined with endometriosis
The analysis of a five-years’ catamnesis of reproductive age women who underwent surgery to remove leiomyoma nodes (myomectomy) is represented in this article. The aim of the study was to determine the incidence of tumor...
Pitavastatin – a new inhibitor of the HMG-CoA reductase: peculiarities of clinical pharmacology and perspectives of its usage in treatment of cardiovascular diseases
Cardiovascular mortality makes up 66.3 % of the total mortality in Ukraine. Myocardial infarction, stroke, atherosclerosis of peripheral arteries are the diseases caused by atherosclerosis and are prevalent in the mortal...
Оценка клинической эффективности комбинированного болеутоляющего средства «Фаниган» при симптоматическом лечении пациентов с болевым синдромом различного генеза
Оцінка клінічної ефективності комбінованого болезаспокійливого засобу «Фаніган» при симптоматичному лікуванні пацієнтів з больовим синдромом різного генезу. Мамчур В.Й., Носівець Д.С., Нальотов С.В., Паламарчук В.І., Гур...
The optimization of treatment of patients with community-acquired pneumonia with high cardiovascular risk (case from practice)
Pneumonia occupies a significant part in the structure of morbidity and mortality of the population of Ukraine and the whole world. The incidence of this disease is several times higher among elderly patients. At the sam...