Modulatory effect of NONI-Herbal formulation against ethylene glycol induced nephrolithiasis in albino rats.
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 3
Abstract
The effect of NONI-herbal formulation against ethylene glycol induced nephrolithiasis in albino wistar rats is summarized in this study. Lithiasis was induced in rats by administering 0.75% ethylene glycol in drinking water for 28 days and was manifested by high urinary calcium, phosphate, oxalate, and low urinary magnesium contents. Simultaneous administration of 1ml (1 in 10) NONI formulation orally for 28 days along with ethylene glycol (0.75% v/v) reduced urinary calcium, phosphate, oxalate and elevated urinary magnesium level. It also increased urinary volume thereby reducing the tendency for crystallization. The histopathological studies confirmed the induction as degenerated glomeruli, necrotic tubule and inflammatory cells was observed in section of kidney from animals treated with ethylene glycol.This was reduced; however after treatment with NONI formulation. These observations enable to conclude that NONI is effective against ethylene glycol induced nephrolithiasis.
Authors and Affiliations
Verma N. K. , Patel S. S. , Saleem T. S. M, Christina A. J. M, Chidambaranathan N.
Keywords
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