Molecular mechanisms of neoplasia
Journal Title: Annales Academiae Medicae Silesiensis - Year 2017, Vol 71, Issue
Abstract
The evolution of normal cells into neoplastic cells involves many stages. This paper describes six characteristics of tumour cells: maintenance of cell division-promoting signals, resistance to exogenous growth inhibitors, avoidance of apoptosis, acquisition of the ability to undergo an infinite number of divisions, induction of angiogenesis as well as activation of the ability to invade and metastasise. The listed and described characteristics of tumor cells are associated with genomic instability and the production of inflammation. Genomic instability protes the formation of a diverse pool of cells, and the accumulation of traits of tumor cells leads to inflammation. The progress of science has enabled the addition of two further features acquired by cells during the process of neoplasia – modification of cellular metabolism and avoidance of recognition by the immune system.
Authors and Affiliations
Alicja Derkacz, Katarzyna Komosińska-Vassev
Keywords
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- EP ID EP359846
- DOI 10.18794/aams/63498
- Views 101
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