Monoamine oxidase inhibitory properties of some benzazoles: Structure-; Activity relationships
Journal Title: The AAPS Journal - Year 1999, Vol 1, Issue 4
Abstract
Benzazoles containing two or three nitrogen atoms were screened for their inhibitory activity toward monoamine oxidases MAO-A and MAO-B. In order to clarify the mechanism of interaction of these compounds with the enzyme, their electronic structure was calculated at the ab initio level and the influence of lipophilicity on activity was investigated. The mode of binding of benzazoles to MAO-B appears different from that of previously investigated heterocycles.
Authors and Affiliations
Teresa Grandi, Fabio Sparatore, Carmela Gnerre, Patrizia Crivori, Pierre-Alain Carrupt, Bernard Testa
Keywords
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- EP ID EP682121
- DOI 10.1208/ps010416
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