Monosodium glutamate below the neurotoxic doses has no cytotoxic effect on mouse mesenchymal stem cells
Journal Title: Cumhuriyet Medical Journal - Year 2017, Vol 39, Issue 3
Abstract
Objective: Monosodium glutamate appear as a food additive that listed in the group of flavor enhancers is continuously used in various types of foods. Monosodium glutamate is the sodium salt of glutamic acid, one of the most abundant naturally-occurring non-essential amino acids. U.S. Food and Drug Administration reported that monosodium glutamate is safe for use in food. However, the excessive use of monosodium glutamate causes dizziness, nausea and vomiting. Due to reports, it causes obesity. In this study it was aimed to find out the cytotoxicity of monosodium glutamate and the role on the selected genes, which have role on obesity. Method: In our study, mice were used which are known to be the most sensitive in terms of toxicity. The cytotoxic effects of monosodium glutamate on mouse mesenchymal stem cells at monosodium glutamate doses below the blood dose (100- 130 µmol/dl) that reported as the neuronal damage threshold in mice were studied. Furthermore leptin-lep and ghrelin / obestatin in prepropeptide-GHRL gene expressions in order to find out the role of monosodium glutamate in obesity were analyzed. Results: Monosodium glutamate below the toxic dose does not have a cytotoxic effect on mouse mesenchymal stem cells. Also no expression change in applied monosodium glutamate doses was observed in genes which are known to be associated with obesity. Conclusions: Our results support that monosodium glutamate has no toxic effect on stem cells in uses in certain doses
Authors and Affiliations
Sinem Dal, Sümeyye Arslan, Nejat Kaan Nurol, Tutku Göktepe, Zehra Dilşad Çoban, Ertan Altaylı, Şefik Güran
Keywords
Related Articles
- EP ID EP238924
- DOI 10.7197/223.v39i31705.347449
- Views 138
- Downloads 0
Transverse mini skin incision for carpal tunnel release
Objective: Mini skin incision technique for median nerve release have become popular recently for the treatment of carpal tunnel syndrome. The main advantages of this technique are shorter recovery time and better cosmet...
Changes emerging with calcinerin inhibition in Caenorhabditis elegans individuals as an aging model
Objective: It is known that calcineurin inhibition prolongs life in individuals with Caenorhabditis elegans (C. elegans). An important part of C. elegans genes shows great similarity to human genes. This study aims to ev...
Evaluation of abdominal aortic aneurysm rupture in emergency department: Case report
Abdominal aortic aneurysm (AAA) is a common chronic degenerative disease of the abdominal aorta leading to progressive dilatation, thrombosis, rupture and distal embolization. It is defined as exceed 30 mm or 50% increas...
Children and health effects of war Being a war child...
It’s predicted that almost 10 million children as died at wars during the last decade, almost 300 thousand children fight more than 30 engagement area. Situations arising from armed conflict effect first of all children...
Effects of oxytocin and oxytocin receptor antagonist atosiban on nociception and morphine analgesia in rats
Objective: Oxytocin is a peptide-based hormone released from the supraoptic nucleus and paraventricular nucleus in the hypothalamus and consisting of nine amino acids. It has been shown that oxytocin may have an effect o...