Mouth dissolving tablets: A current review of scientific literature
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2013, Vol 1, Issue 2
Abstract
The objective of this paper was to review the information about mouth dissolving tablets. Methods to improve patient’s compliance have always attracted scientists towards the development of fancy oral drug delivery systems. Among them, mouth dissolving drug delivery systems (MDDDS) have acquired an important position in the market by overcoming previously encountered administration problems and contributing to extension of patent life. MDDDS have the unique property of rapidly disintegrating and/or dissolving and releasing the drug as soon as they come in contact with saliva, thus obviating the requirement of water during administration. This is seen to afflict nearly 35% of the general population and associated with a number of conditions, like parkinsonism, mental disability, motion sickness, unconsciousness, unavailability of water etc. To overcome such problems, certain innovative drug delivery systems, like ‘Mouth Dissolving Tablets’ (MDT) have been developed. These are novel dosage forms which dissolve in saliva within a few seconds, when put on tongue. Such MDTs can be administered anywhere and anytime, without the need of water and are thus quite suitable for children, elderly and mentally disabled patients. This article describes the existing techniques for fast dissolving oral preparation, highlights their manufacturing processes, evaluation parameters and future trends for these evolving forms. Such MDTs can be administered anywhere and anytime, without the need of water and are thus quite suitable for children, elderly and mentally disabled patients. The excipients that are currently used as well as those that are expected to be used for the future development of improved FDTs are described in the review paper.
Authors and Affiliations
Geetika Sharma, Rupinder Kaur, Sukhdev Singh, Ajay Kumar, Shivani Sharma, Ramandeep Singh, Yogesh Kumar
Keywords
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