MULTIDRUG LOADED GASTRORETENTIVE FILMS FOR THE TRATMENT OF H. PYLORI INFECTION
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2015, Vol 4, Issue 3
Abstract
The objective of the present work was to develop innovative gastro retentive formulation based on mucoadhesive patch systems using the solvent casting technique, allowing a final structure with improved cohesion by mucoadhesive swelling and which releases drugs in the stomach. Chitosan used as a natural polymer, and PAA is a mucoadhesive polymer. The mucoadhesive gastro retentive films bearing amoxicillin trihydrate, metronidazole and famotidine were prepared using solvent casting method. This method provides good drug content uniformity. Various formulation variables i.e. percentage of glycerol plasticizer, concentration of chitosan and chitosan : PAA ratio, which affects the GR films preparation and its characterization were optimized on the basis of their effect on film weight, thickness, folding endurance and tensile strength. The various variables were optimized by varying one variable and keeping other variable constant.
Authors and Affiliations
Sapna Rathore*| Department of Pharmacy, Oriental University, Indore –India, M K Gupta| Department of Pharmacy, Oriental University, Indore –India, Neetesh Kumar Jain| Department of Pharmacy, Oriental University, Indore –India, Ankita Dubey| Department of Pharmacy, Oriental University, Indore –India, Ankit Agrawal| Department of Pharmacy, Oriental University, Indore –India
Keywords
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