Multidrug resistance pattern in bacteriological isolates of neonatal septicemia in NICU of a tertiary care center

Journal Title: Indian Journal of Microbiology Research - Year 2018, Vol 5, Issue 3

Abstract

Introduction: Multidrug resistance pathogens have been found to be an increasing cause of neonatal sepsis in developing country like India. The present study was conducted to study the multidrug resistant pattern in bacterial isolates of neonatal septicaemia in Neonatal intensive care unit (NICU) of a tertiary referral hospital, Northeastern part of U.P., India. Material and Methods: It was a prospective study in which blood culture sample was taken from 450 neonates who had clinical features of sepsis or had presence of risk factors (one major–prolonged rupture of membranes/evidence of chorioamnionitis, intrapartum fever, foul smelling liquor or two minor–febrile illness of mother 2 weeks prior to delivery, meconium stained liquor amnii, more than 3 vaginal examinations during labour, low birth weight or prematurity, prolonged labour, low Apgar score) over a period one year. Results: A total of 102 (22.7%) suspects were found to be positive for sepsis. In present study, among positive cases of neonatal sepsis, the prevalence of early onset was around three forth as compared to late onset sepsis. Among all gram positive and gram negative isolates Klebseilla pneumoniae was found to be maximum followed by Grp B streptococcus. Out of total isolates only five isolates were MDR, whereas 4 MRSA and 17 ESBL. Conclusion: Presence of Multidrug resistant isolates as well an increasing rate of ESBL producers among neonates noted in this study is alarming. Thus regular monitoring of susceptibility profile of bacterial pathogen is the need of the hour to treat and curtail the increasing trend of neonatal septicemia.

Authors and Affiliations

Fareya Haider, Zahida Parveen Dar, Aman Gupta, Shadma Yaqoob, Mastan Singh

Keywords

Related Articles

Control of Pseudomonas aeruginosa blood stream infection outbreak in neonatal intensive care unit by quantitative antibiogram

Introduction: Neonates are very susceptible to Pseudomonas aeruginosa. Single case of Pseudomonas aeruginosa in preterm neonates is a sign for immediate action. Aim: To describe control of an outbreak of Pseudomonas aeru...

Seroprevalence and changing trend of dengue in a tertiary care hospital

Introduction: Dengue fever is a seasonal acute febrile arbo-viral illness ranging from asymptomatic infection to dengue fever and the severe dengue haemorrhagic fever dengue shock syndrome. India is one of the seven iden...

A study on extended spectrum β lactamase & metallo β lactamase producing bacteria from drinking water sources in and around Kelambakkam

Introduction: Water is essential to life and many people do not have access to clean safe drinking water. Poor sanitation is the major cause for water contamination. Death due to infection like cholera, typhoid fever, ba...

Tube adherence test as a screening tool for detection of biofilm formation among Staphylococcus

Background: Due to large number of infections caused by biofilm producing organism, a reliable and reproducible method for its detection is necessary. Specific methods like Polymerase Chain Reaction (PCR) are available f...

Coexistence of quinolone resistance and extended spectrum beta lactamase production in urinary isolates of Escherichia coli - an emerging challenge to antimicrobial prescribing pattern

Background: Urinary tract infections are the second most common infections in community practice and Escherichia coli is the most commonly isolated organism in community acquired UTI. Fluoroquinolones are the preferred a...

Download PDF file
  • EP ID EP471571
  • DOI 10.18231/2394-5478.2018.0065
  • Views 74
  • Downloads 0

How To Cite

Fareya Haider, Zahida Parveen Dar, Aman Gupta, Shadma Yaqoob, Mastan Singh (2018). Multidrug resistance pattern in bacteriological isolates of neonatal septicemia in NICU of a tertiary care center. Indian Journal of Microbiology Research, 5(3), 307-312. https://www.europub.co.uk/articles/-A-471571