Multimodal imaging characteristics of adult-onset foveomacular vitelliform dystrophy
Journal Title: Guoji Yanke Zazhi - Year 2018, Vol 18, Issue 11
Abstract
AIM: To observe the multimodal imaging characteristics of adult-onset foveomacular vitelliform dystrophy(AFVD). <p>METHODS: Retrospective study. Six cases(11 eyes)of AFVD in Zhengzhou Second People Hospital from January 2015 to April 2018 were included. Amongst all of them, there were 2 men 3 eyes, 4 women 8 eyes, aged from 43-67 years(average 52.5±1.7 years). No abnormality was found in the anterior segment, intraocular pressure and electroretinogram(ERG). There was no family history. Best corrected visual acuity(BCVA)was from 0.08-0.8, EOG was normal in 9 eyes, slightly decreased in 2 eyes. Fundus color photography, optical coherence tomography angiography(OCTA), fundus fluorescein angiography(FFA)and indolecyanine green angiography(ICGA)of the patients were examined and analyzed. <p>RESULTS: The fundi of all patients showed less than 1PD vitelliform lesions, showing hypofluorescence in FFA and ICGA. In the late phase of FFA,fluorescence accumulated in the lesion in some patients. In B-scan of OCTA, there was vitelliform substance which deposited between the photoreceptor and retinal pigment epithelium(RPE )layer. As the disease continues to progress, photoreceptor layer became thinner, RPE-Bruch layer became thinner or disappeared. In OCTA there was dark spot with strong reflection around it in choriocapillary layer. There was dark spot in En-face image. <p>CONCLUSION: Multimodal imaging assist in diagnosing AFVD, reducing missed diagnosed and misdiagnosis, better understanding the pathogenesis, developing the treatment plan, judging prognosis.
Authors and Affiliations
Shu Yan
Keywords
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- EP ID EP519743
- DOI 10.3980/j.issn.1672-5123.2018.11.37
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