Multiparameter Flow Cytometry: An Important Auxiliary Tool for The Diagnosis and Differential Diagnosis of Myelodysplastic Neoplasms

Journal Title: Diseases & Research - Year 2023, Vol 3, Issue 1

Abstract

Multiparameter flow cytometry (MFC) shows promise in the diagnosis and differential diagnosis of myelodysplastic neoplasms (MDS). By identifying abnormal immunophenotypes of different cell lineages in bone marrow (BM) cells, MFC can aid in the differential diagnosis of some bone marrow failure diseases. Several flow cytometry scoring systems have been established based on current parameters, but there is still no specific immunophenotype available for the diagnosis of MDS. Morphological examination of cells remains the gold standard for MDS diagnosis. In the future, identifying specific cell immunophenotypes may improve MDS diagnosis and alter the use of MFC. MFC may also provide a solution for tracking the evolution of specific abnormal hematopoietic clones in MDS.

Authors and Affiliations

Siqi Luo, Rong Huang, Shifeng Lou

Keywords

Related Articles

An Analysis of Gut Bacterial and Fungal Community Interactions in Saxifraga stolonifera Curt.-Treated Mice

Backgrounds Saxifraga stoloniferaCurt. is valued for its great medicinal potentials, especially for anti-inflammatory activity. The gut microbiome is gradually regarded as a pivotal part that contributes to the therapeut...

Exploring Oncogenic Factors Influence on Multiple Myeloma Progression and Patient Survival

Backgrounds Multiple myeloma (MM), one of the most prevalent hematological malignancies, is characterized by the proliferation of plasma cells within bone marrow and concurrent development of osteolytic lesions. The pers...

Plasma Exchange to Treat Cytokine Release Syndrome and Immune Effector Cell-Associated Neurotoxicity Syndrome after Anti-CD19 Chimeric Antigen Receptor-T Cell Infusion: A Case Report

Adoptive cell immunotherapy with chimeric antigen receptor-T (CAR-T) cells has shown remarkable clinical out-comes. However, cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICA...

Angioimmunoblastic T Cell Lymphoma Complicated by Cirrhosis Decompensation

A 55-year-old male with a history of hepatitis B was hospitalized for persistent cough, fever, rash, and abdominal bloating. Despite treatment for suspected respiratory infection with multiple antibiotics, his symptoms w...

Characteristics of Patients with Cryptogenic Cirrhosis: A Retrospective Study

Backgrounds This study aimed to achieve a better understanding of the characteristics of patients with cryptogenic cirrhosis (CC). Methods We retrospectively enrolled 50 patients with CC between January 2018 and Decembe...

Download PDF file
  • EP ID EP740145
  • DOI 10.54457/DR.202301005
  • Views 97
  • Downloads 0

How To Cite

Siqi Luo, Rong Huang, Shifeng Lou (2023). Multiparameter Flow Cytometry: An Important Auxiliary Tool for The Diagnosis and Differential Diagnosis of Myelodysplastic Neoplasms. Diseases & Research, 3(1), -. https://www.europub.co.uk/articles/-A-740145