Multiple colon perforation as a fatal complication during treatment of metastatic melanoma with ipilimumab – case report
Journal Title: Polish Journal of Surgery - Year 2014, Vol 86, Issue 2
Abstract
Ipilimumab, an anticancer drug, is an anti-CTLA4 monoclonal antibody. It is used in treatment of disseminated melanoma. Therapy is associated with high risk of complications. One of the most serious, although one of the rarest is perforation of gastrointestinal tract. In this case report we describe a 52-year old male, with disseminated melanoma with unknown starting point, treated with antiCTLA4 monoclonal antibody. After 3rd dose of drug administration, bloody diarrhea and acute abdominal pain occurred as a symptom of gastrointestinal perforation. A single perforation was sutured during laparotomy. Symptoms of acute abdomen returned after 10 days. Pus-faecalperitonitis, symptoms of necro-hemorrhagic colitis and multilocal perforation of the colon were found during relaparotomy. Pancolectomy with end ileostomy was performed. Few hours since relaparotomy pacient died due to multiple organ failure. The purpose of this case report is to draw attention to a risk of multilocal colon perforation in patient treated with ipilumumab.
Authors and Affiliations
Paweł Dilling, Jakub Walczak, Wiesław J. Kruszewski
Keywords
Related Articles
- EP ID EP74379
- DOI 10.2478/pjs-2014-0017
- Views 141
- Downloads 0
Long-term results of incisional hernia repair with concomitant abdominoplasty in postbariatric patients
The aim of the study was evaluation of long-term results after simultaneous incisional hernia repair and abdominoplasty in patients following RYGB (Roux-en-Y Gastric By-pass) and estimation of quality of life before and...
Foreign Body in the Gastrointestinal Tract Leading to Small Bowel Obstruction - Case Report and Literature Review
The presence of a foreign body in the gastrointestinal tract constitutes a common pathology, considering surgical clinical practice. The management of the ingestion of a foreign body depends on many factors. The study pr...
Comparison of lymphatic system staging classifications in patients with gastric cance
Despite an observed decrease in the incidence of gastric cancer, it still remains an important clinical problem. It is the fourth most common cancer in the world and the second cause of death in cancer patients. The qual...
Abdominal cavity eventration treated by means of the „open abdomen” technique using the negative pressure therapy system – case report and literature review
Wound dehiscence is a surgical complication in which the wound ruptures along the surgical suture with abdominal cavity bowel displacement. It is observed in 0.2‑6% of operated patients. The extensive wound is a gateway...
Odległe wyniki jednoczasowej plastyki pooperacyjnej przepukliny i abdominoplastyki u pacjentów leczonych operacyjnie z powodu otyłości patologicznej
Celem pracy była cena odległych wyników po jednoczasowej abdominoplastyce z plastyką przepukliny w bliźnie pooperacyjnej (ominięcie żołądka – RYGB) oraz porównanie jakości życia pacjentów przed i po operacji jednoczasowe...