MULTIVARIATE CHEMOMETRIC MODELS USED FOR THE ANALYSIS OF RAFOXANIDE IN PRESENCE OF ITS ALKALINE DEGRADATION PRODUCT
Journal Title: Innoriginal: International Journal Of Sciences - Year 2018, Vol 5, Issue 2
Abstract
Objective: Development and validation of three simple, accurate and precise chemometric models for the determination of rafoxanide in the presence of its alkaline degradation product without preliminary separation. Methods: These methods are classical least square (CLS), principal component regression(PCR) and partial least square (PLS-1). A 2-factor 5-level experimental design was built leading to 25 mixtures containing different ratios of rafoxanide and its alkaline degradation product. Thirteen mixtures were used as a training set, and the other twelve were used as a validation set. Results: Using of multi-wavelengths instead of the single wavelength spectrophotometry has greatly improved the precision and predictive abilities of these multivariate calibrations. Conclusion: The proposed methods have been found to be accurate, precise and can be used for determination of the drug in pure form and pharmaceutical formulations as well as in the presence of its degradation product without any preliminary separation steps.
Authors and Affiliations
AHMED H. ABDEL-MONEM, MOHAMMED W. I. NASSAR, KHALID A. M. ATTIA, AHMAD A. MOHAMAD, RAGAB A. M. SAID
Keywords
Related Articles
- EP ID EP550300
- DOI -
- Views 117
- Downloads 0
AN EPIDEMIOLOGICAL SURVEY OF HYPERTENSION
Epidemiological surveys of hypertension on 500 volunteers were conducted, in which 137 volunteers were hypertensive. During the Epidemiological study, it was observed that sedentary life style, āmapradoshaka aahar & viha...
MATHEMATICAL PROCESSING FOR SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF CYCLOPENTOLATE AND PHENYLEPHRINE IN THEIR BINARY MIXTURE
Objective: Development and validation of three simple, accurate, selective and and low cost spectrophotometric methods for simultaneous determination of cyclopentolate hydrochloride (CLO) and phenylephrine hydrochloride...
A PROMISING APPROACH TO ENHANCE SOLUBILITY AND BIOAVAILABILITY BY SELF EMULSIFYING DRUG DELIVERY SYSTEM: A BRIEF REVIEW
Objective: The formulation of self-emulsifying drug delivery system of drugs is to enhance the solubility and bioavailability. More than 40% of available drugs exhibit poor water solubility, resulting in unsatisfactory o...
A REVIEW ON BUCCAL PATCHES
The aim of this article is to study the buccal patches. Buccal patch is a nondissolving thin matrix modified release dosage form composed of one or more polymer films or layers containing the drug and/or other excipients...
REDUCING POSTHARVEST LOSSES IN NIGERIA’S AGRICULTURAL SECTOR: PATHWAY TO SUSTAINABLE AGRICULTURE.
The study focused primarily on postharvest losses which are like a recurring decimal in Nigeria’s agricultural sector, the driving factors and proactive measures that can be adopted to tackle the problem. Nigeria’s popul...