MUPIROCIN RESISTANCE IN CLINICAL ISOLATES OF STAPHYLOCOCCUS AUREUS IN A TERTIARY CARE HOSPITAL SET UP IN NORTH INDIA
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2013, Vol 2, Issue 4
Abstract
Background: Mupirocin is a topical antibiotic used for nasal decolonisation of methicillin resistant Staphylococcus aureus (MRSA). While resistance to mupirocin has been described it is usually not tested for in most clinical laboratories. Aim: The present study was carried out to detect the occurrence of mupirocin resistance in clinical isolates of Staphylococcus aureus in a tertiary care hospital set up in northern India. Materials and Methods: Staphylococcus aureus isolates obtained from clinical samples received in the microbiology laboratory over a period of one year were included in this study. Mupirocin resistance was detected by three phenotypic methods; disk diffusion method using 5µg and 200µg mupirocin disk to determine low-level and high-level resistance, broth microdilution method and an agar dilution method for determining minimum inhibitory concentrations. Methicillin sensitivity was also determined in the study isolates. Results: Of 250 non-duplicate Staphylococcus aureus isolates obtained, 5 (2%) were found resistant to mupirocin. All mupirocin resistance isolates were shown to have high-level resistance (minimum inhibitory concentration > 512µg/ml). All mupirocin resistant isolates were also resistant to methicillin. Results obtained by all three phenotypic methods showed good correlation. Conclusion: High-level mupirocin resistance is present in the northern Indian population which may be of major concern to prevent the spread of MRSA in hospitals and community.
Authors and Affiliations
Singh Amit K| Postgraduate Department of Microbiology, King George Medical University, Lucknow, U.P, India, Corresponding author email: amit.singh.dr@gmail.com, Venkatesh Vimala| Postgraduate Department of Microbiology, King George Medical University, Lucknow, U.P, India, Singh Mastan| Postgraduate Department of Microbiology, King George Medical University, Lucknow, U.P, India
Keywords
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- EP ID EP11066
- DOI 10.5958/j.2319-5886.2.4.134
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