Natural Polymer from Sesamum radiatum as an Emulsifier and Stabilizer in Fabrication of Macroemulsions
Journal Title: Journal of Pharmaceutical Research International - Year 2015, Vol 8, Issue 4
Abstract
Aim: Sesamum gum was extracted from the leaves of Sesamum radiatum and evaluated as emulsifier or stabilizer in coarse emulsions. Methods: The emulsion systems were assessed by monitoring of emulsion density, viscosity, globule size, and by evaluating the effects of temperature and salt over a four week period. Results: It was observed that the known 4:2:1 ratio did not form emulsions when sesamum was used but other ratios such as 2:4:1, 2:4:0.5, 2:4:0.25 and 2:4:0.125 formed emulsions. The emulsions were however, unstable. When sesamum gum was used as a stabilizing agent (0.4%/v – 2.0%/v), and acacia (7.5%/v) as an emulsifying agent, stable emulsions were formed. At the end of four weeks, the emulsion systems exhibited lower globule sizes (1.68-1.95 µm) than the emulsion systems containing acacia alone (3.95 µm) as emulsifier. The emulsions creamed or cracked when exposed to temperatures of about 40°C over 4 weeks. They were however stable even in the presence of salt of 1.0%/v concentration. Conclusion: The presence of sesamum as a stabilizer influenced the globule size and size distribution, the viscosity and consequently the stability of the emulsions. The study suggests that sesamum gum possesses the desirable properties of emulsifier/stabilizer in emulsions.
Authors and Affiliations
Ndidi C. Ngwuluka, Edith O. Ugwuagbo, Elijah I. Nep, Patrick O. Olorunfemi, Patricia O. Odumosu, Nelson A. Ochekpe
Keywords
Related Articles
- EP ID EP344455
- DOI 10.9734/BJPR/2015/19729
- Views 121
- Downloads 0
General Anaesthesia for Cesarean Section in a Parturient with Long QT Syndrome: A Case Report and a Review of Literature
Long QT syndrome patients are at high risk of developing ventricular arrhythmia and cardiac arrest, so that the anesthetic technique used for these patients must avoid anything that will induce an arrhythmia such as tach...
In vitro Antimicrobial Activity of Fruit Pulp Extracts of Azanza garckeana (F. Hoffm.) Exell & Hillc. and Isolation of One of its Active Principles, Betulinic Acid
Aims: To perform anti-microbial activity guided isolation and to characterize compound(s) from fruit pulp (extracts) of Azanza garckeana. Place and Duration of Study: Department of chemistry, University of Agriculture,...
Analgesic and Anti-inflammatory Activities of the Fruit Extract of Ampelocissus latifolia (Roxb) on Laboratory Animals
Aim of Study: This study was aimed to evaluate the possible analgesic and anti-inflammatory properties of the ethanol extract of fruit of Ampelocissus latifolia (Roxb). Study Design: Assessment of analgesic and anti-inf...
Effect of Andrographis serpyllifolia Leaves Extract on Experimentally Induced Typhoid Using Salmonella Typhi
Aims: The aim of the study was to evaluate the effect of the standardized ethanolic extract of Andrographis serpyllifolia leaves on experimentally induced typhoid. Study Design: Single dose of 1 ml Salmonella Typhi (106...
Determination of Vitamin B6, B9 and B12 in Halophytes by Solid Phase Extraction Followed by HPLC-UV
In this work, solid phase extraction (SPE) was proposed for simultaneous determination of trace levels of vitamin B6, B9 and B12. High performance liquid chromatography with UV detection (HPLC-UV) was used. The experimen...