A CLINICO-MICROBIOLOGICAL STUDY OF OSTEOMYELITIS IN A TERTIARY CARE HOSPITAL IN KARNATAKA
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2016, Vol 5, Issue 1
Abstract
BACKGROUND Bone and joint infections are painful for patients and frustrating for both doctors and patients. Osteomyelitis presents a variety of challenges to the physician. The severity of the disease is staged depending upon the infection’s particular features, including its aetiology, pathogenesis, extent of bone involvement, duration, and host factors. The high success rates of antimicrobial therapy in most infectious diseases have not yet been achieved in bone and joint infections. AIM To determine the microbiological profile and antibiotic susceptibility patterns of organisms isolated from cases of osteomyelitis. METHODS Pus samples were collected for bacterial culture from 90 cases of osteomyelitis between June 2013 and August 2015 and processed in the laboratory. RESULTS Among the 90 patients studied, most of them were men (79), with median age group 30-50 years, affected by chronic osteomyelitis (77%) or acute osteomyelitis (22%), with predominant involvement of lower limbs (90.5%). A total of 70 isolates of bacteria were obtained from 90 clinical samples. The most frequently isolated pathogens were Staphylococcus aureus (51.4%), Klebsiella pneumoniae (11.4%), Enterococcus faecalis (8.5%), Pseudomonas aeruginosa and Proteus mirabilis (7%). Susceptibility of gram positive organisms to linezolid, tetracycline, vancomycin and gentamicin was 100%. Gram negative organisms are highly susceptible to aminoglycosides, levofloxacin, piperacillin and tazobactam (87.5%). Four methicillin resistant Staphylococcus aureus were isolated. CONCLUSION Osteomyelitis remains a serious therapeutic challenge, especially when associated with gram negative bacteria. We emphasize the need to consider these agents in diagnosed cases of osteomyelitis, so that an ideal antimicrobial treatment can be administered since the very beginning of the therapy
Authors and Affiliations
Anjana Gopi , Syeda Ul Khair, Hitha Kottileveetil , Divya Harindranath, Vinoba Sabapathy
Keywords
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- EP ID EP112518
- DOI 10.14260/jemds/2016/4
- Views 112
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