A Focus on Quinolones and its Medicinal Importance
Journal Title: International Journal of Novel Trends in Pharmaceutical Sciences - Year 2011, Vol 1, Issue 1
Abstract
Quinolones are a very important family of antibacterial agents that are widely prescribed for the treatment of infections in humans. Quinolones comprise a relatively large, growing and most interesting group of antibacterial drugs which have made a major impact on the field of antimicrobial chemotherapy. Since their discovery in the early 1960s, the quinolone group of antibacterials has generated considerable clinical and scientific interest. The bacterial type II topoisomerases, DNA gyrase and topoisomerase IV are validated targets for clinically useful quinolone antimicrobial drugs. A significant limitation to widely utilized quinolone inhibitors is the emergence of drug-resistant bacteria due to an altered DNA gyrase. Antibiotic drug choice will remain difficult in the presence of increasing resistance, but introduction of the new quinolones has created a new and exciting era in antimicrobial chemotherapy.
Authors and Affiliations
N Saravana kumar, D Dhivya, B Vijayakumar
Keywords
Related Articles
- EP ID EP156796
- DOI -
- Views 91
- Downloads 0
RP-HPLC method development and validation of valizodone in pure and tablet dosage form
A simple, precise, rapid, accurate and economic reverse phase high performance liquid chromatographic method has been developed for the estimation ofValizodone in tablet dosage form. The separation was achieved by using...
In-Silico Molecular Docking Analysis of Cancer Biomarkers with Bioactive Compounds of Tribulus terrestris
Currently, in the research scenario for cancer, the identification of anti-cancer drugs using immuno-modulatory proteins and other molecular agents to initiate apoptosis in cancer cells and to inhibit the signalling path...
Molecular Mechanics and 3D structure validation studies on PCO and Hypothyroidism (SHBG) gene using Insilico protocols
It has been estimated by the World Health Organization that PCOs affects 116 million women worldwide as of 2010 (3.4% of women). In the United States hyperthyroidism affects about 1.2% of the population. About half of t...
Comparative studies of microbial efficiency based on different dissolved oxygen (DO) concentration in the tannery effluent
A Effluent samples were collected from a tannery in Ambur, Vellore Dist, Tamil Nadu, India. The physio-chemical parameters of the effluent viz, colour, odour, pH, Electrical conductivity, TSS, TDS, BOD, COD, total hardne...
Development of New Spectrophotometric Methods for the Determination of Perindopril in Pharmaceutical Dosage Forms
Three simple and sensitive Spectrophotometric methods have been developed for the determination of Perindopril (PDL) in pure and pharmaceutical dosage forms. Method A is based on the formation of Ion-assosiation complex...