A review on chemistry and biological significance of benzimidaole nucleus
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 12
Abstract
Benzimidazole is a heterocyclic aromatic organic compound. It is an important pharmacophore and privileged structure in medicinal chemistry. It plays a very important role with plenty of useful therapeutic activities such as: antiulcers, antihypertensives, analgesic, anti-inflammatory, anti-virals, antifungals,anticancers, and antihistaminics. The review of the literature shows that the benzimidazole derivatives are outstandingly effective compound and number of reviews available for biochemical and pharmacological studies conformed that their molecules are useful against a wide variety of micro-organisms. Because of their importance, the methods for their synthesis have become a focus of Synthetic Organic Chemists. Therefore in the present review we tried to compile the chemistry of different derivative of substituted benzimidazole as well as various pharmacological activities and some of the important methodologies used for the synthesis.
Authors and Affiliations
Nomi Srestha , , Janmajoy Banerjee , Sujiti Srivastava
Keywords
Related Articles
- EP ID EP147904
- DOI -
- Views 105
- Downloads 0
Physiological effect of Natural Penicillin Extract on Cassava Peel Media by Penicillium chrysogenum PCL501 on E.coli Infected Wistar Rats
ABSTRACT:- Some physiological effect of natural penicillin extract produced on cassava peel media by Penicillium chrysogenum PCL501 on E.coli infected Wistar rats were evaluated. Fermentation of P. chrysogenum PCL501 wit...
Combination of Angkak (Red Yeast Rice), Red Guava (Psidium guajava Linn) Leaf Extract and Red Guava Fruit J
: Dengue fever leads to decrease in the number of thrombocytes. Objective of this research was to study the effect of combination of angkak (red yeast rice), Psidium guajava fruit juice, and P. guajava leavesextra...
[b]PHARMACOGNOSTICAL & PRILIMINARY PHYTOCHEMICAL STUDY OF HIPTAGE BENGHALENSIS (L) KURZ[/b]
Assessment of Good Pharmacy Practice (GPP) in Pharmacies of Community Settings in India
: Good Pharmacy Practice (GPP) is at the very heart of the profession of Pharmacy; indeed it is the very essence of the profession. Moreover, it expresses our covenant with the patient not only to ‘do no harm’ bu...
[b] Hepatoprotective and antioxidants activity of ethanolic extract of Cuscutta reflexa roxb[/b]