Alteration of liver function and glycated haemoglobin (HbA1C) in type 2 diabetes mellitus
Journal Title: Journal of Medical Science and Technology - Year 2015, Vol 4, Issue 2
Abstract
Alanine aminotransferase (ALT) is the most specific marker of hepatic pathology. Glutamyl transferase (GGT) is considered to be a sensitive indicator of liver damage but not specific. Obesity also has major affects on GGT. The National Cholesterol Education Program has proposed a definition of the metabolic syndrome to help identify individuals at risk for both coronary heart disease and type 2 diabetes. A total of 90 subjects (60 type 2 diabetic subjects, 30 healthy subjects) in an age group of 30 – 75 years satisfying inclusion criteria were selected for the study. Biochemical parameters like fasting and post prandial blood sugar, total serum cholesterol, total triglycerides, HDL, LDL, HbA1C, ALT, AST and GGT were measured using quantitative enzymatic method in Dimension – R fully automated biochemistry analyzer. In our study the Mean ± S.D values of Gamma Glutamyl Transferase, Alanine Aminotransferase, Aspartate Amino Transferase and Glycated Haemoglobin (Hba1c) was significantly elevated among cases when compared to controls (p value <0.001). The Mean ± S.D value of Hba1c was elevated in cases when compared to controls. (p value <0.001). Increase in the levels of ALT and GGT in our study supports the theory that the liver functions may get altered due to diabetes.
Authors and Affiliations
Somisetty sagarika, T kumar, S Vijaya, Mundlamudi Naidu
Keywords
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