Anti diabetic and Anti hyperlipidemic activity of bark of Bruguiera gymnorrhiza on streptozotocin induced diabetic rats
Journal Title: Asian J of Pharm Sci & Tech - Year 2011, Vol 1, Issue 1
Abstract
ABSTRACT . The present study was aimed to evaluate the anti diabetic - activity potential of Bruguiera gymnorrhiza bark against streptozotocin (STZ) induced experimental rats. Ethanolic extract of roots of Bruguiera gymnorrhiza (EEBG) was administered to streptozotocin induced rats. Glibenclamide was used as a standard drug. Blood glucose levels were determined after oral administration of a dose of Bruguiera gymnorrhiza (400 mg/kg b. wt) in diabetic groups. Blood glucose levels were determined on 0, 7th, 14th and 21st day after oral administration of ethanolic extracts of Bruguiera gymnorrhiza (400 mg/kg). An ethanolic extract of Bruguiera gymnorrhiza was found to reduce blood sugar in streptozotocin induced diabetic rats. Reduction in blood sugar could be seen from 7th day after continuous administration of the extract. The effect of extracts of Bruguiera gymnorrhiza on serum lipid profile like Total cholesterol, triglycerides, low density, very low density and high density lipoprotein were also measured in the diabetic and non diabetic rats. There was significant reduction in Total cholesterol, LDL cholesterol, VLDL cholesterol and improvement in HDL cholesterol in diabetic rats. These results indicated that Bruguiera gymnorrhiza possesses a hypoglycemic and antihyperlipidemic effect. Key words: Bruguiera gymnorrhiza, Glibenclamide, Hypoglycemia, Antihyperlipidemic, Streptozotocin
Authors and Affiliations
* Sk. Karimulla, B. Pavan Kumar
Keywords
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