Anti-inflammatory and anti-pyretic properties of Spirulina platensis and Spirulina lonar: A comparative study
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2014, Vol 27, Issue 5
Abstract
Spirulina spp. is a blue-green algae belongs to the family of Oscillatoriaceae, which having diverse biological activity. The aim of this current study was to evaluate and compare the anti-pyretic and anti-inflammatory activity of Spirulina platensis/SP and Spirulina lonar/SL extracts. In the anti-pyretic study, the ability to reduce the rectal temperature of rats induced pyrexia with 2g/kg Brewer’s Yeast (BY) was performed. Rats were dosed either 2 or 4 mg/kg SP or SL. Rectal temperature was taken every hour for 8 hours. Results shown that there were significant dose-dependent (p<0.05) reduction of both treatments. However, SP treatment revealed faster reduction in rectal temperature. For anti-inflammatory activity, the reduction in the volume of paw edema induced by Prostaglandin E2 (100 IU/rat intraplantar) was measured. Rats were dosed orally with 2 or 4 mg/kg SP or SL. The paw edema was measured every 30 minutes for 4 hours using plethysmometer. Results had shown a significant dose dependent reduction in diameter of paw edema (p<0.05). The finding suggests that SP and SL extracts have anti-pyretic and anti-inflammatory properties. However, SP was found to be more effective than SL as anti-pyretic and anti-inflammatory agent.
Authors and Affiliations
Nor Azura Mohamed , Zuraini Ahmad , Zainul Amiruddin Zakaria , Lokman Shamsuddin , Mohd Sofian Omar Fauzee , Arifah Abdul Kadir
Keywords
Related Articles
- EP ID EP94566
- DOI -
- Views 119
- Downloads 0
In vitro evaluation of antimicrobial activity of Kutajghan vati – An Ayurvedic formulation
The present investigation focuses to determine the antimicrobial potential of an Ayurvedic formulation Kutajghan vati. In this study the activity of this formulation was compared with the standard antibiotics like Amikac...
Role of the antidiabetic drugs: Glibenclamide and metformin on the contractility of isolated rat uteri
The current investigation has designed to study the role of two antidiabetics, glibenclamide and metformin on the spontaneous uterine contractions in the non-diabetic non-pregnant female rats. The rat uteri were is...
Enhanced Ehrlich tumor inhibition using DOX-NP and gold nanoparticles loaded liposomes
Treatment with doxorubicin (DOX) is a common treatment for different types of cancer. DOX-NP is one of a well established marketed liposomal formulation for DOX. It has advantages over free DOX in reducing the card...
Immunoreactivity and two-dimensional gel-electrophoresis characterization of Egyptian cobra venom proteome
The first and second (two) dimensional gel electrophoresis has a broad protein resolution power. It was used to separate and identify cobra venom proteome. The importance of characterizing venom proteins contents f...
To study the influence of different grades of Ethylcellulose ether derivative polymer Ethocel® and co-excipient on drug release profile of controlled release matrix tablet of acarbose
The aim of the study presented is to formulate and evaluate Acarbose controlled release matrix tablets by means of different grades of polymer Ethocel and different co-excipients with the intention to see their eff...