Anti-inflammatory and anti-pyretic properties of Spirulina platensis and Spirulina lonar: A comparative study

Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2014, Vol 27, Issue 5

Abstract

 Spirulina spp. is a blue-green algae belongs to the family of Oscillatoriaceae, which having diverse biological activity. The aim of this current study was to evaluate and compare the anti-pyretic and anti-inflammatory activity of Spirulina platensis/SP and Spirulina lonar/SL extracts. In the anti-pyretic study, the ability to reduce the rectal temperature of rats induced pyrexia with 2g/kg Brewer’s Yeast (BY) was performed. Rats were dosed either 2 or 4 mg/kg SP or SL. Rectal temperature was taken every hour for 8 hours. Results shown that there were significant dose-dependent (p<0.05) reduction of both treatments. However, SP treatment revealed faster reduction in rectal temperature. For anti-inflammatory activity, the reduction in the volume of paw edema induced by Prostaglandin E2 (100 IU/rat intraplantar) was measured. Rats were dosed orally with 2 or 4 mg/kg SP or SL. The paw edema was measured every 30 minutes for 4 hours using plethysmometer. Results had shown a significant dose dependent reduction in diameter of paw edema (p<0.05). The finding suggests that SP and SL extracts have anti-pyretic and anti-inflammatory properties. However, SP was found to be more effective than SL as anti-pyretic and anti-inflammatory agent.

Authors and Affiliations

Nor Azura Mohamed , Zuraini Ahmad , Zainul Amiruddin Zakaria , Lokman Shamsuddin , Mohd Sofian Omar Fauzee , Arifah Abdul Kadir

Keywords

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  • EP ID EP94566
  • DOI -
  • Views 120
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How To Cite

Nor Azura Mohamed, Zuraini Ahmad, Zainul Amiruddin Zakaria, Lokman Shamsuddin, Mohd Sofian Omar Fauzee, Arifah Abdul Kadir (2014).  Anti-inflammatory and anti-pyretic properties of Spirulina platensis and Spirulina lonar: A comparative study. Pakistan Journal of Pharmaceutical Sciences, 27(5), 1277-1280. https://www.europub.co.uk/articles/-A-94566