Anticancer activity of Cinnamon tamala leaf constituents towards human ovarian cancer cells
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 3
Abstract
Bioassay guided fractionation of Cinnamon tamala leaf extracts yielded bornyl acetate (1), caryophylene oxide (2), p-coumaric acid (3) and vanillic acid (4) using A-2780 human ovarian cancer cell lines. The structures of the isolated compounds were confirmed through spectroscopic techniques (EIMS, 1 H and 13C NMR). Compound 1 exhibited highest cytotoxicity with 90.16±1.06% inhibition (IC50=5.30 x 10-4 mg/ml) followed by compound 2 (84.40±1.53% inhibition; IC50=8.94 x 10-3mg/ml), while compounds 3 and 4 were inactive in the bioassay.
Authors and Affiliations
Durre Shahwar , Sami Ullah , Mohammad Akmal Khan , Naeem Ahmad , Afifa Saeed , Saif Ullah
Keywords
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