Biological interaction of stress and irritable bowel syndrome
Journal Title: International Journal of Medical Science and Public Health - Year 2014, Vol 3, Issue 10
Abstract
A variety of stressors play a role in the development of irritable bowel syndrome. Irritable bowel syndrome is a biopsychosocial disorder that results from dysregulation of central or enteric nervous system function. The physiological effects of psychological and physical stressors on gut function and brain-gut interactions are mediated by outputs of the emotional motor system in terms of autonomic, neuroendocrine, attentional, and pain modulatory responses. Certain investigational studies reported to date indicate that the activation of CRF1 pathways may result in a combination of effects that are key features of symptoms in some irritable bowel syndrome patients. These include stimulation of colonic motility, defecation or watery diarrhea, gut hypersensitivity that increases the perception of stimuli within the bowel, focused attention (hypervigilance) toward the gut sensations, and mast cell activation. Blocking the CRF1 receptors may alleviate all these effects. Stress thus can be included in an integrative model explaining the pathophysiology of functional bowel disorder. Advances in the understanding of the relationship between stress and visceral perception may constitute a basis for a therapeutic approach of functional bowel disorders targeted on the central nervous system
Authors and Affiliations
Niraj Saptoka, Dev Shah, Nazrul Islam
Keywords
Related Articles
- EP ID EP95363
- DOI 10.5455/ijmsph.2014.150920141
- Views 133
- Downloads 0
Gender disparity in health and nutritional status among under-five children in a rural field practice area of Shri BM Patil Medical College
Background: It is the right of every child to know and be cared for by his/her parents. The responsibilities for the child’s well-being rely on both the parents and the society. Since the ancient times, it is the gen...
OCT determined macular thickness in diabetic retinopathy and relation to colour vision deficiency patterns
Background: Diabetic retinopathy is the most common cause of blindness in industrialised nations and the incidence of diabetes is expected to rise over the next 10 years. Early treatment of proliferative diabetic...
Diastolic dysfunction in apparently healthy individuals: A single center experience based on echocardiography
Background: As the process of myocardial remodeling starts before the onset of symptoms, detection of subclinical left ventricular diastolic dysfunction is of paramount importance. This will help in the early implementat...
A cross-sectional assessment of attitude and practice toward Hepatitis B among primary health care workers in Aljouf region of Saudi Arabia
Background: Hepatitis B (HB) is a global public health problem infecting nearly 2 billion people around the globe. Health- care workers (HCWs) remain at a high-risk of acquiring and transmitting the disease. Objectiv...
Psychological well-being and burden in caregivers of patients with schizophrenia
Background: There is a de fi nite paucity of Indian studies looking into the caregiver burden, psychological well-being, and the interface between them. Objectives: This work aims to study the correlation between t...