Clinical research on postoperative efficacy and related factors of early simulation hyperbaric oxygen therapy for severe craniocerebral injury

Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2016, Vol 29, Issue 1

Abstract

 In order to discuss the clinical efficacy of simulation hyperbaric oxygen therapy(HBOT) for severe craniocerebral injury and analyze the related factors of it, 108 patients who transferred to our department during December 2010 - December 2014 for ventilator treatment after operation of severe craniocerebral injury were taken as the subjects of the study. These patients were divided into conventional treatment group and simulation hyperbaric oxygen therapy group to contrast the curative effects. At the meantime, GOS score and length of stay in intensive care unit (ICU) of two groups 6 months after treatment, as well as changes in the indexes of the HBO group during treatment were performed statistical analysis. Then factors affecting prognosis of simulation HBOT were performed regression analysis and principal component analysis. The results showed that when compared to the control group, differences in cases with four GOS score and one GOS score in the treatment group were significant (p<0.05). Jugular venous oxygen saturation (SjvO2), jugular bulb oxygen partial pressure (PjO2), arterial partial pressure of oxygen (PaO2) and arterial oxygen saturation (SaO2) of the simulation HBO group before the first time treatment on the first day and after the first time treatment on the third day were significantly increased, with statistical significance (p<0.05); serum lactic acid (Lac) and blood glucose (Glu) decreased significantly (p<0.05). Prior to and during the first treatment on the first day, jugular bulb pressure (Pj) and central venous pressure (CVP) had no significant difference (p>0.05). Regression analysis indicated that factors affecting prognosis included cerebral contusion, coronary heart disease, hydrocephalus and tracheotomy. Principal component analysis found the factors were hydrocephalus, coronary heart disease, tracheotomy, cerebral contusion, cerebral infarction and glasgow coma scale (GCS) before treatment. Therefore, stimulation HBOT can significantly improve the prognosis of patients with severe craniocerebral injury. Paying attention to risk factors in clinics and giving timely interventional treatment can reduce morbidity and mortality in patients.

Authors and Affiliations

LanjuanXu , Baolin Li , Caifu Yang , Chengjian Li , Yueli Peng

Keywords

Related Articles

 Hepatoprotective activity of hepatoplus on isonaizid and rifampicin induced hepatotoxicity in rats

Present study deals with the hepatoprotective activity of polyherbal formulation Hepatoplus (HP) as an oral supplement to the INH and RIF induced hepatitis in experimental rats. Rats treated with INH and RIF show abnorma...

 Preliminary evaluation of antimicrobial activity of cream formulated with essential oil of Trachyuspermum ammi

 : In our present research we studied physiochemical properties and antimicrobial activity of T. ammi (Trachyuspermum ammi) seeds. The seeds yielded 2.86% essential oil. Refractive index, specific gravity, acid valu...

 Unraveling the molecular mechanism governing the tissue specific expression of IFNλR1

 The functional receptor for type III interferons (IFNs) is a heterodimer of IFNLR1 and IL10R2. IFNLR1 is expressed in a highly tissue specific manner, with epithelial and liver tissue as the prime expressing tissue...

 Therapeutic effects of total alkaloids of Fructus Hordei Germinatus in hyperprolactinemis rats

Fructus Hordei Germinatus is widely used in treating hyperprolactinemia as a kind of Chinese traditional herb in China. However, its active composition of curing hyperprolactinemia remains unclear. This study investigate...

 Prostate cancer: Leading and misleading routes to TRAIL of death

 Prostate cancer is a multifaceted disease that arises because of misrepresentation of linear and integrated signaling cascades that regulate gene network in normal and cancer cells. Programmed cell death is modu...

Download PDF file
  • EP ID EP112349
  • DOI -
  • Views 119
  • Downloads 0

How To Cite

LanjuanXu, Baolin Li, Caifu Yang, Chengjian Li, Yueli Peng (2016).  Clinical research on postoperative efficacy and related factors of early simulation hyperbaric oxygen therapy for severe craniocerebral injury. Pakistan Journal of Pharmaceutical Sciences, 29(1), 273-280. https://www.europub.co.uk/articles/-A-112349