Clinical study of ganglioside (GM) combined with methylprednisolone (MP) for early acute spinal injury
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 2
Abstract
This paper aims to make an analysis of the effects of ganglioside (GM) combined with methylprednisolone (MP) in early acute spinal injury. Fifty-three patients with acute spinal cord injury were included in this study and they were randomly divided into experimental and control group. Twenty-seven patients in the control group were treated with MP, while the rest 26 patients received more GM based on that. By observing and comparing the clinical responses from patients and recovery time of all indexes, results came out: the curative rates in the experimental and control group were 50.0%, 40.7% respectively, and the total effective rates were 92.3%, 85.2% respectively. There was a remarkable difference between the two groups (P<0.05). Patients in the experimental group took 6.2±1.9d to restore their sphincter function, 11.2±2.8d to recover their muscle forces to over grade II, and 13.8±3.9d to return general activity, while the patients in the other group clearly spent longer time on recovery, that were 12.1±3.2, 19.2±4.6 and 23.9±5.6 respectively. The distinct difference between the two groups was of statistical significance (P<0.05). We conclude that GM has better curative effects than MP, for it is able to promote the recovery of nerve function for patients and greatly improve the prognosis.
Authors and Affiliations
Dayong Xu , Libin Yang , Yunpeng Li , Yongqiang Sun
Keywords
Related Articles
- EP ID EP111211
- DOI -
- Views 92
- Downloads 0
Generation of recombinant bioluminescent Escherichia coli for quantitative determination of bacterial adhesion
Bacterial adhesion to urinary catheter was evaluated by measuring the light emitted from a recombinant bioluminescent glycocalyx producer Escherichia coli strain. Generation of the bioluminescent strain was carried...
Antibacterial and antifungal activities of leaf extract of Achyranthes aspera (Amaranthaceae) from Pakistan
Alcoholic extract and various fractions of Achyranthes aspera leaves, traditionally used in Pakistan for treatment of infectious diseases was screened for in vitro antibacterial and antifungal activity. The chlorof...
Combined use of borneol or menthol with labrasol promotes penetration of baicalin through rabbit cornea in vitro
The permeability of most drugs through the eyes is very limited, so finding safe and effective penetration enhancers is of high importance in current ophthalmology research. In this paper, we use a new approach tha...
Ethambutol-Cobalt (II) ions complexation spectral characteristics and applications for quantitative analysis
Ethambutol (EMB) has no significant absorption characteristics beyond 200 nm due to its aliphatic saturated nature. Thus, direct EMB determination in the UV range is not feasible due to its very low molar absorptiv...
Pharmacological rational of dry ripe fruit of Aegle marmelos L. as an anti-nociceptive agent in different painful conditions
The aim of study is to investigate central and peripheral analgesic effects of methanolic extract of dry ripe fruit of Aegle marmelos Linn. Corea (Am. Cr) by two methods, tail flick test and acetic acid induce...