COMPARATIVE EVALUATION OF ACAMPROSATE WITH OTHER DRUGS IN CENTRAL TINNITUS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2013, Vol 2, Issue 11
Abstract
[b]AIM[/b]: To compare the efficacy of acamprosate with other drugs to decrease the severity of sensorineural tinnitus. [b]MATERIAL AND METHOD[/b]: The study was randomised double-blind, placebo controlled, crossover. Forty adult subjects (>18 years of age), of either sex with tinnitus of sensorineural origin, were administered either acamprosate 333 mg tds or matched placebo for a period of six weeks followed by a washout period of one week. Drug therapy was switched for another six weeks in consonance with the crossover design. The effect of acamprosate and placebo on subjective relief and objective improvement was evaluated by using modified tinnitus severity quality of life scores and audiometry with tinnitus matching in frequency and loudness. [b]RESULTS[/b]: At the end of study the drug had shown a statistically significant improvement in reducing the tinnitus score in 92.5% of the patients and placebo with an improvement in 12.5% of the patients in contrast to other drugs belonging to this group. [b]CONCLUSION[/b]: Acamprosate is an effective drug in treating the severity of sensorineural tinnitus
Authors and Affiliations
Sharanjit Kaur, Harinder Singh, Naresh Jyoti
Keywords
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- EP ID EP100967
- DOI 10.14260/jemds/428
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