Correlation of Estrogen and Progesterone Receptor expression in Breast Cancer
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2015, Vol 5, Issue 11
Abstract
Breast cancer is the most common malignant tumor among women. It accounts for 22% of all female cancers; more than twice the prevalence of cancer in women at any other site. Immunohistochemistry (IHC) is now the globally accepted methodology for detection of estrogen (ER) and progesterone (PR) receptors in breast carcinomas. The present study is designed for further insight into age and biology of ER and PR expression pattern in breast cancer patient of Bihar, India. Samples were obtained from biopsy and analyzed for ER/PR expression through Immunohistochemistry (IHC). Data were collected and statistically analyzed. It was observed that mean age of ER+ positive breast cancer patients were 47 years, while mean age of PR positive patient were 44 years. Two third patients had either ER or PR is positive while one third had both negative. In our study we observed 6.4 % patients with ER negative and PR positive. Thus it is concluded that two third of breast cancer patients was positive for hormone receptor. ER/PR positive indicates over-expression of estrogen and progesterone in carcinoma breast. ER negative and PR positive group was also observed in significant number of breast cancer patients. ER negative were observed in early age group of breast cancer while PR negative were observed in higher age group patients
Authors and Affiliations
Vinita Trivedi , Ranjit Kumar , Rita Rani , Anita Kumari , Richa Chauhan, , Arun Kumar , Md Ali
Keywords
Related Articles
- EP ID EP106637
- DOI -
- Views 97
- Downloads 0
Sensitivity and specificity of 99m Tc-UBI29-41 and 67 Ga-Citrate scintigraphy imaging to discriminate infection lesion induced by Staphylococcus aureus and sterile inflammation lesion induced by Carrageenan in foot’s rat
This study was launched to evaluate the efficacy and efficiency of 99m Tc-UBI29-41scintigraphy imaging to visualize the infection foci induced by staphylococcus aureus and inflammation lesions induced by carra...
Antibiotic resistance patterns of methicillin-resistant Staphylococcus aureus (MRSA) isolated from chronic skin ulcer of patients in Kaduna state, Nigeria.
The aim of this study is to investigate the antibiotic resistance patterns of methicillin - resistant Staphylococcus aureus (MRSA) isolated from out - patients with chronic skin ulcer in four different ho...
Extraction of Squid (Photololigo Duvaucelii) Myofibrillar and Sarcoplasmic Proteins to Create A Skin Prick Test Reagent In The Diagnosis of Food Allergy
The major and minor allergens in fish and shellfish that have been identified are broadly spread in the myofibrillar and sarcoplasmic proteins. This study aimed to create the SPT reagents of squid myofibrillar an...
Protective Potential of Aqueous Leaf Exract of Vernonia amygdalina in Cyclophosphamide – Induced Myelotoxicity
Cyclophosphamide (CP) is among the most widely used alkylating anti-cancer agents in chemotherapy. Myelotoxicity is one of its dose-limiting adverse effects. The aim of the present study, therefore, was to investigate th...
Outcome of pregnancy among Pre-existing Type-2 Diabetic Women
Background: Diabetes mellitus is now one of the most common non-communicable diseases globally. As diabetes is a chronic and debilitating disease, it may have adverse effect on pregnancy and pregnancy outcomes. Aim...