DESIGN AND IN VIVO EVALUATION OF GASTROINTESTINAL MUCOADHESIVE PATCH SYSTEM (GMPS) LOADED WITH CHITOSAN NANOPARTICLES
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2014, Vol 4, Issue 4
Abstract
ABSTRACT A novel gastrointestinal mucoadhesive patch system was designed to improve the oral bioavailability of macromolecular therapeutics using chitosan nanoparticles for effective delivery of macromolecules (using FITC-Dextran as model drug). The patch system consisted of mucoadhesive layer containing the drug and backing layer made of water-impermeable polymer. The gastrointestinal mucoadhesive patch (GMP) was formulated using 10% ethyl cellulose in 80:20 dichloromethane:methanol along with triethyl citrate as plasticizer. The mucoadhesive layer was formulated using 2% carbopol dispersion in water along with 30% propylene glycol as a plasticizer. Pharmacokinetic study was done in rabbits for FITC-Dextran solution, patch containing FITCDextran incorporated in to the mucoadhesive layer filled into enteric coated capsules and patch containing FITC-Dextran incorporated chitosan nanoparticles loaded in to the mucoadhesive layer filled inside enteric coated capsules. FITC-Dextran was found to be 1.16 times more bioavailable orally from chitosan nanoparticle loaded in mucoadhesive layer as compared to other prepared formulations. Keywords: Patch system, FITC-Dextran, Chitosan nanoparticles, Mucoadhesion, Gastrointestinal, Pharmacokinetics.
Authors and Affiliations
Samir Kalavadia1 , Ranjeet Prasad Dash2 , Manju Misra1 , Manish Nivsarkar2,*
Keywords
Related Articles
- EP ID EP123152
- DOI -
- Views 100
- Downloads 0
“AAVARAI KUDINEER”- A POTENT POLYHERBAL SIDDHA FORMULATION FOR MANAGEMENT OF DIABETES MELLITUS
ABSTRACT Diabetes mellitus is caused due to deficiency in production of insulin. It is a global problem and number of those affected is increasing day by day. Oral hypoglycemic agents use is restricted by their p...
THE BIONIC EYE
ABSTRACT Aim of bionic eye is to restore vision to patients who have gone blind due to macular degeneration or retinitis pigmentosa. In the past 20 years, biotechnology has become the fastest-growing area of scie...
DEVELOPMENT AND VALIDATION OF DAPOXETINE IN PURE AND SOLID DOSAGE FORM BY HPTLC METHOD
An HPTLC method has been developed for the estimation of Dapoxetine in bulk and solid dosage form. It employs pre coated plates by using silica gel 60 F 254(2×10 cm, thick ness of layer 0.2 mm) as stationary phas...
FORMULATION DEVELOPMENT AND EVALUATION OF POTASSIUM CHLORIDE EXTENDED RELEASE TABLETS
Potassium chloride is an electrolyte replenisher used in the treatment of hypokalemia. It has a short biological half-life of 1 to 1.5hours. It is a freely soluble drug in the gastric contents while taking it ora...
IN-VITRO ANTI INFLAMMATORY ACTIVITY OF ULTRA SONIC BATH ASSISTED, METHANOL EXTRACT OF LEPIDIUM SATIVUM LINN. SEEDS
Plants can provide biologically active molecules and lead structures for the development of modified derivatives with enhanced activity and reduced toxicity. There are certain problems associated with use of anim...