DEVELOPMENT AND VALIDATION OF NEW SPECTROPHOTOMETRIC METHODS FOR THE QUANTITATIVE ESTIMATION OF SILODOSIN IN BULK DRUG AND PHARMACEUTICAL FORMULATIONS
Journal Title: Int J of Preclin & Pharm Res - Year 2014, Vol 4, Issue 1
Abstract
ABSTRACT Three simple, sensitive, accurate and rapid spectrophotometric methods A, B and C have been developed for the quantitative estimation of Silodosin in bulk drug and also pharmaceutical formulations. Method A is a UV-spectrophotometric method in which Silodosin was dissolved in alcohol showing גmax 269nm.The method is linear in the concentration range of 10-50g/ml. Methods B and C are based on oxidation followed by complex formation reaction. In method B and C Silodosin reacts with 1,10-phenanthroline and 2,2’-bipyridyl to form orange red colored chromogen which shows maximum absorbance at 507nm and 518nm for methods B and C respectively. Linearity range for method B was between 2-10g/ml and that for method C was between 4-20g/ml. Results of the analysis were validated statistically. All the validation parameters were within the acceptable range and prove the precision, sensitivity and applicability of the methods for the routine quantitative determination of Silodosin in its dosage form. Keywords: Silodosin, 1,10-phenanthroline, 2,2’-bipyridyl, UV-Spectrophotometer.
Authors and Affiliations
Karazgi Kishwar Jahan * and Malipatil SM
Keywords
Related Articles
- EP ID EP133503
- DOI -
- Views 118
- Downloads 0
MICROSPONGES: A NOVEL DRUG DELIVERY SYSTEM FOR CONTROLLED DELIVERY OF TOPICAL DRUGS
ABSTRACT Even though possess several advantages topical formulations have some drawbacks such as the need to contain high concentrations of active agents for effective therapy due to the low efficiency of deliver...
AN OVERVIEW OF ELECTRON PROBE MICROANALYSIS
ABSTRACT Electron Probe Microanalysis (EPMA) is an analytical technique that is used to establish the composition of small areas on specimens. It’s one of the several particle-beam techniques These analytical te...
ANTIOXIDANT DEFENSE ENZYMES ACTIVITY IN HYPOBARIC HYPOXIA SUSCEPTIBLE AND TOLERANT SPRAGUE DAWLEY RATS
ABSTRACT Antioxidant enzymes are known defense molecules, which eliminate reactive oxygen species (ROS) and free radicals that damage useful enzymes in the cell under various stress conditions. Significant effort...
MUCOADHESIVE VAGINAL DRUG DELIVERY SYSTEM: A REVIEW ON ADVANCE STATUS
ABSTRACT Mucoadhesive delivery systems offer several advantages over other oral controlled release systems by virtue of prolongation of residence time of drug, its targeting, and localization of the dosage form a...
ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY: AN INTRODUCTION AND REVIEW
ABSTRACT Ultra Performance Liquid Chromatography (UPLC) is a relatively new technique giving new possibilities in liquid chromatography, especially concerning decrease of time and solvent consumption. UPLC chroma...