ETHNOPHARMACOLOGICAL STUDIES ON ANTISPASMODIC, BRONCHODILATOR AND ANTIPLATELET AGGREGATION ACTIVITIES OF BLEPHARIS EDULIS , PERS
Journal Title: ASIAN JOURNAL OF NATURAL & APPLIED SCIENCES - Year 2012, Vol 1, Issue 1
Abstract
Blepharis edulis, Pers. is traditionally used for gastrointestinal, respiratory and inflammatory disorders. The Aim of the studywas to rationalize the medicinal use of Blepharis edulis in gastrointestinal, respiratory and inflammatory disorders. The aqueous-ethanolic extract of Blepharis edulis seed (Be.Cr) was studied for its antispasmodic and bronchodilator effect on the isolated rabbit jejunum and tracheal preprations respectively and for antiplatelet effect using ex vivo model of human platelets. Results were: Be.Cr tested positive for alkaloids, flavonoids, tannins, sterols, terpenes ,phenolic compounds and saponins. Be.Cr (0.01-3.0mg/ml) produced relaxation of spontaneous and K+ (80mM)-induced contractions .The calcium channel blocking (CCB) effect was confirmed when Be.Cr shifted the Ca++ dose-response curves (DRCs) to right similar to verapamil. In isolated rabbit tracheal preparation, it caused inhibition of high K+-induced contractions at low dose(0.03-1.0 mg/ml) and carbachol (1μM)- induced contraction at high dose(0.01-3.0 mg/ml). Verapamil produced similar effect on high K+ and carbachol(1μM)-induced contraction suggestive of bronchodilatory effect mediated possibly through CCB. Be.Cr inhibited ADP-induced platelet aggregation (0.5- 1.5 mg/ml) at relatively high concentration than epinephrine induced aggregation (0.125- 1.0 mg/ml). The study showed the presence of spasmolytic and bronchodilator activity in dried seed of Blepharis edulis mediated possibly through blockade of Ca++ channels along with antiplatelet activity which provides sound pharmacological basis for its medicinal use in gut motility, respiratory and inflammatory disorders.
Authors and Affiliations
Fatima Saqib, Khalid Hussain Janbaz, Muhammad Farhaj Latif, Anwarul Hassan Gilani, Samra Bashir
Keywords
Related Articles
- EP ID EP108966
- DOI -
- Views 146
- Downloads 0
HUMIDITY EFFECTS AND MITIGATION ON GENERATORS IN THE COASTAL AREAS OF NIGERIA
Owing to unreliable electricity supply from the national grid, petrol generators are now an essential part of the energy supply in Nigeria. But Nigeria’s climatic environment affects the operation of these generators. Th...
ADAPTATION TO THE HARSH CONDITIONS OF THE ARID AND SEMI- ARID AREAS OF KENYA: IS PASTORALISM THE BEST LIVELIHOOD OPTION?
Pastoralism is a subsistence pattern in which people make a living through dependence on livestock. With the right social and political support the pastoral economy can thrive and contribute to the national economy. Drou...
THE QUALITY OF HOME HEALTHCARE SERVICE IN RIYADH/SAUDI ARABIA
Background: Home healthcare services are expanding in Saudi Arabia at a rapid pace in order to meet the need of growing population of older adult and those with chronic illnesses and the quality of this service is variou...
EFFECTS OF ORGANIC CARBON AND DISSOLVED OXYGEN ON SPECIES DIVERSITY OF LITTORAL BENTHOS IN SITES AROUND THE RUMUEME CREEK IN THE UPPER BONNY ESTUARY
A study was conducted to evaluate the organic carbon and dissolved oxygen (DO) conditions of surface sediments and water samples and their effects on species diversity of the littoral macro...
ON THE ISSUES OF TRIAGE IN CONSERVATION
The process of determining the priority of patients’ treatment based on the severity of their condition is termed triage. This principle attempts to ration the treatment of patients efficiently in the midst of insufficie...