Evaluation and comparison of different brands of domperidone tablets available in Karachi, Pakistan
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2014, Vol 27, Issue 4
Abstract
Domperidone is an anti-dopaminergic drug used for the treatment of nausea, vomiting and dyspepsia. It has also been used in Parkinson’s disease. In this study, five different brands of Domeperidone tablets were selected from the local market for evaluation of their quality as the local market is occupied of many competitors for a single generic. The evaluation of Domperidone tablets was done using various pharmacopoeial and non-pharmacopoeial tests. All the test results fell within BP specified limits for all the selected brands i.e. the results for Brands A to E for weight variation, thickness and diameter were satisfactory and within limits. For Brands A to E, the results for hardness and friability were also satisfactory i.e. 4-10kg/cm2and 0.1-0.6% respectively. The results for Brands A to E for disintegration were 2-6 minutes; for dissolution and assay, the results were 89-92% and 95-99% respectively. The results of similarity factor (f2)also showed that all brands of Domperidone have comparative dissolution profiles.
Authors and Affiliations
Muhammad Qamar Khan , Nighat Razvi , Fakhsheena Anjum , Lubna Ghazal , Saeed Ahmed Siddiqui , Muhammad Harris Shoaib
Keywords
Related Articles
- EP ID EP99724
- DOI -
- Views 129
- Downloads 0
In vitro screening of mucus and solvent extracts of Eisenia foetida against human bacterial and fungal pathogens
Earthworms are macro invertebrate and have been widely used as therapeutic drugs for thousands of years. In the current research, experiments viz., the antibacterial, antifungal and antioxidant activity of mucus an...
Comparing the effects of salts of diclofenac and almioprofen with aspirin on serum electrolytes, creatinine and urea levels in rabbits
The effects of diclofenac sodium, diclofenac potassium, alminoprofen and aspirin on serum electrolytes (serum Na+ and K+), urea and creatinine were compared in rabbits in acute and chronic phases of treatment. The data s...
Preparation of bisoprolol fumarate nasal spray and its nasal delivery in rats
The aim of the present work was to prepare a nasal spray of bisoprolol fumarate (BF). The Pharmacokinetics and relative bioavailability of the BF nasal formulation were evaluated in Wistar rats. The BF nasal spray...
Influence of high intensity focused ultrasound (HIFU) treatment to the pancreatic function in pancreatic cancer patients
Present study was designed to investigate the pancreatic endocrine and exocrine function damage after High Intensity Focused Ultrasound (HIFU) therapy in patients with advanced pancreatic cancer. It was a retrospective a...
An old dietary regimen as a new lifestyle change for Gastro esophageal reflux disease: A pilot studyAn old dietary regimen as a new lifestyle change for Gastro esophageal reflux disease: A pilot study
Treatment of gastro esophageal reflux disease (GERD) is becoming a challenge for medical profession. Proton pump inhibitors (PPIs) are commonly recommended but many disadvantages of these drugs are being reported,...