Evaluation of Oxidative Markers, Apoptosis and Reproductive Efficiency in Heroin Addicted Rats
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2013, Vol 3, Issue 10
Abstract
Background and Objective: Heroin abuse and addiction represent one of the major problems globally. The objective of this study is to evaluate the oxidative stress enzyme markers, apoptosis, sperm quality and testosterone of heroin administered rats via intraperitoneal injection. MATERIALS AND METHODS: Thirty male rats were randomly allocated into three groups. Frst group regarded as control, while in group2 and 3, the animals were daily injected intraperitoneally with (1 and 5 mg Heroin/kg b.w.) for seven successive days. Enzymatic activities of alkaline phosphatase (ALP), Xanthine Oxidase (XO), Glucose-6-phosphate dehydrogenase (G6PDH) and lactate dehydrogenase (LDH) in serum were analyzed, and concentration of Malondialdehyde (MDA) and testosterone hormone assayed, besides determining the percent count of hepatocyte apoptosis and sperm head abnormalities. RESULTS: The activity of XO, G6PDH and LDH significantly changed, whereas ALP not affected. The lipid peroxidation marker (MDA) significantly elevated in high dose treatment. The mean percent of apoptotic hepatocytes count reported a clear increase in concentration dependent manner. Also heroin showed significant impact on testosterone level, and sperm head abnormalities counting as well. CONCLUSION: This finding suggests that intraperitoneal injection of heroin cause alteration in oxidation processes, reproductive efficiency and apoptosis mostly in concentration dependent manner.
Authors and Affiliations
Goran Qader Othman
Keywords
Related Articles
- EP ID EP104510
- DOI -
- Views 126
- Downloads 0
[b] A comparative evaluation of in vitro growth inhibitory activities of different solvent extracts of some medicinal plants in Northern Ghana against selected human pathogens[/b]
Production of shell eggs enriched with n-3 fatty acids
Unsaturated long chain fatty acids (n-3 FAs) have been proposed in a human diet to reduce the risk of atherosclerosis and therefore the risk of stroke. N-3 FAs also play an important role in retinal and brain ...
Potency of Nanopropolis Stinglessbee Trigona spp Indonesia as Antibacterial Agent
Propolis is one of the natural produced by honey bee which have many benefits, due to its properties as antibacterial, antivirus, and anticancer. The aim of this study is to determine potency of nanopropolis ho...
Oral Health and its Association with Cardiovascular Disease
ardiovascular disease (CVD) accounts for 29% of deaths worldwide, and CVD contributes 39% of deaths annually in the United States. There is a link between oral health and cardiovascular disease. Recently concern...
Antibacterial potency of fortified and unfortified honey on some clinical bacterial isolates
ABSTRACT: The use of herbal medicine to treat infection has been practiced since the origin of mankind, and honey produced by Apis mellifera is one of the oldest traditional medicines considered important in t...