Evaluation of Oxidative Markers, Apoptosis and Reproductive Efficiency in Heroin Addicted Rats
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2013, Vol 3, Issue 10
Abstract
Background and Objective: Heroin abuse and addiction represent one of the major problems globally. The objective of this study is to evaluate the oxidative stress enzyme markers, apoptosis, sperm quality and testosterone of heroin administered rats via intraperitoneal injection. MATERIALS AND METHODS: Thirty male rats were randomly allocated into three groups. Frst group regarded as control, while in group2 and 3, the animals were daily injected intraperitoneally with (1 and 5 mg Heroin/kg b.w.) for seven successive days. Enzymatic activities of alkaline phosphatase (ALP), Xanthine Oxidase (XO), Glucose-6-phosphate dehydrogenase (G6PDH) and lactate dehydrogenase (LDH) in serum were analyzed, and concentration of Malondialdehyde (MDA) and testosterone hormone assayed, besides determining the percent count of hepatocyte apoptosis and sperm head abnormalities. RESULTS: The activity of XO, G6PDH and LDH significantly changed, whereas ALP not affected. The lipid peroxidation marker (MDA) significantly elevated in high dose treatment. The mean percent of apoptotic hepatocytes count reported a clear increase in concentration dependent manner. Also heroin showed significant impact on testosterone level, and sperm head abnormalities counting as well. CONCLUSION: This finding suggests that intraperitoneal injection of heroin cause alteration in oxidation processes, reproductive efficiency and apoptosis mostly in concentration dependent manner.
Authors and Affiliations
Goran Qader Othman
Keywords
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