Exogenetic insulin increased bone mineral densityin middle-aged male patients with type 2 diabetes mellitus
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 6
Abstract
We aimed to evaluate the influence of exogenetic insulin on bone mineral density (BMD) in Type 2 Diabetes Mellitus (T2DM). Group A included 120 cases of middle-aged male patients with type 2 diabetes mellitus were administrated exogenetic insulin (40 cases in Group A1: for less than 1 year; 40 cases in Group A2:for 1 to 3 years; 40cases in Group A3: for 3 to 5 years), and another 120 cases (Group B) of middle-aged male patients with type 2 diabetes mellitus were administrated insulin secretagogues. The measurements of BMD of lumbar vertebra (L2-4), collum femoris and total body were conducted with dual-energy X-raya bsorptiometry, followed by the determination of glycosylated hemoglobin, plasma insulin concentration (fasting and postprandial), and fasting C-peptide. Our results revealed that there was no statistical difference of BMD (P>0.05) between patients in Group A1or A3andpatients in Group B (B1, B2 or B3), while the BMD in Group A2 increased significantly (P<0.05). And the fracture risk in Group A3 increased significantly (P<0.05) compared with Group B (B1, B2 or B3), Taken together, exogenetic insulin significantly increased BMD and fracture risk of middle-aged male patients with type 2 diabetes mellitus.
Authors and Affiliations
Kaijian Hou , Chuanjian Lin , Qiuming Chen , Xuhuang Wang , Dan Zhu , Chao Chen
Keywords
Related Articles
- EP ID EP95813
- DOI -
- Views 102
- Downloads 0
Synthesis, characterization and antibacterial activity of colloidal NiO nanoparticles
The Colloidal solutions of nickel oxide (NiO) nanoparticles synthesized via Nd-Yag pulse ablation of nickel immersed in H2O were studied. The created nanoparticles were characterized by UV-VIS absorption, Fourier t...
Physicochemical properties, in vitro release and skin permeation studies of a topical formulation of standardized pomegranate rind extract
The aim of the present study was to develop a stable formulation containing standardized pomegranate rind extracts (SPRE) for topical use in the treatment of dermal diseases. Ellagic acid (EA) as the major active c...
Comparative polyphenolic content and antioxidant activities of Genista tinctoria L. and Genistella sagittalis (L.) Gams (Fabaceae)
The aim of this study was focused on the polyphenolic composition and antioxidant capacity of Genista tinctoria L. and Genistella sagittalis (L.) Gams. A qualitative and quantitative characterization of the main ph...
Coumarins and flavonoid from Murraya paniculata (L.) Jack: Antibacterial and anti-inflammation activity
The ethyl acetate extract of leaves of Murraya paniculata (L.) Jack was described in the previous in vitro study on the inhibition effect on the growth of periodontopathic bacteria and the reduction of cytokines fr...
Effects of spironolactone towards rabbit atrial remodeling with rapid pacing
This study aimed to observe the effects of spironolactone towards the rabbit atrial remodeling with rapid atrial pacing (RAP). 30 rabbits were randomly divided into control group, RAP group and spironolactone group...