Exploiting the interaction of polymethacrylates with iron oxide for the enhancement of mucoadhesive strength
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2014, Vol 27, Issue 2
Abstract
Abstract: The present investigation was aimed at preparation of polymethacrylate(s)- iron oxide conjugates and to evaluate mucoadhesive performance using texture analyzer. Eudragit RL-iron oxide or Eudragit RS-iron oxide conjugate granules were prepared by solvent evaporation technique. The mucoadhesive strength of pure Eudragit RL and RS was found to be 11.25±2.02 and 7.78±0.92 g respectively, whereas the same was found to be 36.42±4.01 and 24.32±4.44 for the iron oxide conjugates of Eudragit RL and RS respectively. Hence, mucoadhesive strength of polymethacrylates was found to be enhanced by this technique while, retaining their pH resistant property. A correlation (p>0.05) of 0.97 between mucoadhesive strength and zeta potential indicated conjugation of iron oxide contributed positive surface charge that causes enhancement of mucoadhesion. Further, the ATR-FTIR spectral analysis as well as DSC analysis supported existence of ionic interactions between conjugates (Eudragit RS or RL with iron oxide) and the tissue surface. Hence, the findings point out toward the expected potential use and application of Eudragit RL-iron oxide conjugate in mucoadhesive drug delivery systems, gastro retentive drug delivery systems, etc.
Authors and Affiliations
Inderbir Singh , Vikas Rana
Keywords
Related Articles
- EP ID EP93952
- DOI -
- Views 124
- Downloads 0
Conformational analysis and geometry optimization of buspirone-A 5-HT1A receptor agonist
Buspirone, a partial 5-HT1A receptor agonist, is a clinically prescribed anxiolytic. In the present study, conformational analysis and geometry optimization of buspirone were done as per Hartree-Fock (HF) calculati...
Docking studies on the interaction of flavonoids with fat mass and obesity associated protein
Obesity is the excessive fat accumulation in human body leading to increases a risk of various chronic diseases such as diabetes, cardiovascular diseases, cancer and osteoarthritis. Several flavonoids are known to...
Evaluation of MTANNs for eliminating false-positive with different computer aided pulmonary nodules detection software
MTANN (Massive Training Artificial Neural Network) is a promising tool, which applied to eliminate false-positive for thoracic CT in recent years. In order to evaluate whether this method is feasible to eliminate f...
Detection and adequacy assessment of erythrocyte glutathione transferase on the cycle toxin level of hemodialysis patient
To explore detection and adequacy evaluation of erythrocyte glutathione S transferase (GST) in hemodialysis patients on circular toxin levels, this paper divided 84cases of long-term hemodialysis end-stage patients...
Development and evaluation of omeprazole pellets fabricated by sieving-spheronization and extrusion – spheronization process
Pelletized dosage forms can be prepared by different methods which, in general, are time consuming and labor intensive. The current study was carried out to investigate the feasibility of preparing the spherical pe...