FORMULATION AND EVALUATION OF MICROSPHERES FOR IMMEDIATE AND SUSTAINED RELEASE OF DIFFERENT DRUGS USING SAME POLYMER
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2014, Vol 4, Issue 1
Abstract
Dosage forms that can precisely control the release rates and target drugs to a specific body site have made an enormous impact in the formulation and development of novel drug delivery systems. Microspheres form an important part of such novel drug delivery systems. They have varied applications and are prepared using different polymers. Certain problems regarding the drugs like high first pass metabolism, also the bioavailability of the certain drugs varies due to the instability in acidic environment of stomach. Hence, to resolve such problems the drug should be incorporated in the microspheres for sustained release using a suitable polymer. Natural polymer like chitosan gained great interest in pharmaceutical sector because of its advantages like biodegradability, biocompatibility, non-toxicity, non-immunogenicity and low cost. The current research will be oriented towards the formulation and evaluation of polymeric microspheres of different drugs like atorvastatin calcium and amlodipine and investigate the release profile of such drug using the same polymer chitosan
Authors and Affiliations
Shivhare UD* , Singare SS , Mathur VB
Keywords
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