FORMULATION AND EVALUATION OF ZOLMITRIPTAN RAPIMELTS
Journal Title: Asian J of Pharm Sci & Tech - Year 2015, Vol 5, Issue 1
Abstract
ABSTRACT The purpose of this study is to prepare controlled release Zolmitriptan rapimelts. These rapimelts are in the form of tablets which were prepared by direct compression. Polymers such as HPMC K15M, ethyl cellulose were used to prepare minimatrices which were further converted to micromatrices. Micromatrices were evaluated for different parameters such as drug content, flow properties, percentage yield, moisture content, taste evaluation and drug release. Based on the drug content and drug release optimized formulation of HPMC and ethyl cellulose were used to prepare rapimelts. The physicochemical compatibility of the drug with other excipients used in the formulations was studied by FTIR analysis. The results obtained showed no physicochemical incompatibility between the drug and other excipients used in the formulations. The prepared Tablets were evaluated for different parameters such as thickness, weight variation, hardness, friability, drug content, disintegration time, water absorption ratio, wetting time, dispersion time and wetting volume. The Tablets were also evaluated for in vitro drug release in 0.1N HCl for 24hrs in USP Type II dissolution apparatus. In order to determine the mode of release, the data was fitted into various kinetic models and the optimized formulations followed Krosmeyer peppas model and Higuchi model respectively and n values less than 0.5which indicates Fickian diffusion mechanism of drug release. Key words: Zolmitriptan, Micromatrices, Rapimelts, Controlled release, HPMC, Ethylcellulose.
Authors and Affiliations
T. Lavanya*, K. Navaneetha, P. Naga Haritha, B. Venkateswara Reddy
Keywords
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