GENETICALLY INHERITED HEMOGLOBINOPATHIES: A BIOMEDICAL CONNOTATION ON THALASSEMIA AND SICKLE CELL ANEMIA
Journal Title: Asian J of Pharm Sci & Tech - Year 2015, Vol 5, Issue 4
Abstract
ABSTRACT Thalassemia and Sickle cell anemia are genetic disorders or hemoglobinopathies which are also called inborn error of metabolism. These disorders are caused by genetic error of a heme-protein which carries the oxygen within red blood cells. Therefore, untreated inherited hemoglobin disorders called thalassemia and sickle cell anemia that may become progressively lethal and result to death of patients. Their lethal effect of untreated hemoglobin disorders is increased the clinical and socioeconomic burden of genetic disorders following their epidemiological transition. Hence, it must be to control the ill effects of thalassemia and sickle cell anemia by improving the hygiene, nutrition, genetic counseling, socio-ethical awareness, early prognosis and diagnosis to treat these disorders lead to reduced mortality. Babies born with these disorders are now able to survive long enough if they might be able to get effective diagnosis and treatment to reduce their fatal effects along with family awareness and their parental genetic counseling. These blood disorders are found to be reported throughout the Mediterranean regions, Turkey, Indian subcontinent, West Asia and North Africa. Although, its patho-epiodemiological endurance is going to be worsen in Sub-Saharan Africa as a major national health burden. So, this swift review might be assisted the various global government and private health agencies to understand the future extent of prevalence of this major clinical health problem as well as to develop programs to control and manage these genetically disorders worldwide. Key words: Sickle cell anemia; Thalassemia; Hemoglobinopathies; Sickle cell disease; Genetic hemoglobin disorders; Inborn error of metabolism.
Authors and Affiliations
Kirti Rani*
Keywords
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